Cambendazole

Title: Cambendazole
CAS Registry Number: 26097-80-3
CAS Name: [2-(4-Thiazolyl)-1H-benzimidazol-5-yl]carbamic acid 1-methylethyl ester
Additional Names: 2-(4-thiazolyl)-5-benzimidazolecarbamate isopropyl ester; 5-isopropoxycarbonylamino-2-(4-thiazolyl)benzimidazole; 5-isopropoxycarbonylaminothiabendazole; isopropyl 2-(4-thiazolyl)-5-benzimidazolecarbamate
Manufacturers' Codes: MK-905
Trademarks: Camvet (Merck & Co.); Noviben (Merck & Co.)
Molecular Formula: C14H14N4O2S
Molecular Weight: 302.35
Percent Composition: C 55.61%, H 4.67%, N 18.53%, O 10.58%, S 10.61%
Literature References: Prepn and activity studies: Hoff, Fisher, ZA 6800351 (1969 to Merck & Co.), C.A. 72, 90461q (1970); Hoff et al., Experientia 26, 550 (1970). Clinical studies with sheep, cattle and swine: Egerton et al., Res. Vet. Sci. 11, 193, 495, 590 (1970).
Properties: Odorless, white crystalline solid, mp 238-240° (dec). Sol in alcohol, dimethylformamide; sparingly sol in acetone; slightly sol in benzene; very slightly sol in 0.1M HCl. Practically insol in isooctane and water (0.02 mg/ml). Stable in acid and base in range of pH 1 to 12. uv max (0.1N HCl): 319, 232 nm (A1%1cm 740, 670).
Melting point: mp 238-240° (dec)
Absorption maximum: uv max (0.1N HCl): 319, 232 nm (A1%1cm 740, 670)
Therap-Cat-Vet: Anthelmintic.
Cameleons Camostat Camphene Camphoric Acid Camphotamide