Title: Captodiamine
CAS Registry Number: 486-17-9
CAS Name: 2-[[[4-(Butylthio)phenyl]phenylmethyl]thio]-N,N-dimethylethanamine
Additional Names: 2-[p-(butylthio)-a-phenylbenzylthio]-N,N-dimethylethylamine; p-butylmercaptobenzhydryl b-dimethylaminoethyl sulfide; p-butylthiodiphenylmethyl 2-dimethylaminoethyl sulfide; captodiam; captodramin
Molecular Formula: C21H29NS2
Molecular Weight: 359.59
Percent Composition: C 70.14%, H 8.13%, N 3.90%, S 17.83%
Literature References: Prepn: Hübner, Petersen, US 2830088 (1958). Pharmacological studies: R. Kopf, I. Moller-Nielsen, Arzneim.-Forsch. 8, 154 (1958).
Derivative Type: Hydrochloride
CAS Registry Number: 904-04-1
Trademarks: Covatine (Bailly); Covatix (Gecke); Suvren (Ayerst)
Molecular Formula: C21H29NS2.HCl
Molecular Weight: 396.05
Percent Composition: C 63.69%, H 7.63%, N 3.54%, S 16.19%, Cl 8.95%
Properties: Crystals, mp 131-132°. LD50 (96 hr) in mice, rats (mg/kg): 180, 343 i.p.; 1630, 3800 orally (Kopf, Moller-Nielsen).
Melting point: mp 131-132°
Toxicity data: LD50 (96 hr) in mice, rats (mg/kg): 180, 343 i.p.; 1630, 3800 orally (Kopf, Moller-Nielsen)
Therap-Cat: Anxiolytic.
Keywords: Anxiolytic.
Capuride Caraway Carazolol Carbachol Carbacrylic Resins

Systematic (IUPAC) name
Clinical data
AHFS/ International Drug Names
Legal status Prescription only
Routes Oral
Pharmacokinetic data
Excretion Renal
CAS number 486-17-9
ATC code N05BB02
PubChem CID 10240
ChemSpider 9823 YesY
UNII H93K9455DD YesY
KEGG D07316 YesY
Chemical data
Formula C21H29NS2 
Mol. mass 359.594 g/mol
 YesY (what is this?)  (verify)

Captodiame (INN), also known as captodiamine, is an antihistamine sold under the trade names Covatine, Covatix, and Suvren which is used as a sedative and anxiolytic. It is a derivative of diphenhydramine.[1]

A 2004 study suggested captodiame may be helpful in preventing benzodiazepine withdrawal syndrome in people discontinuing benzodiazepine treatment.[1]