Title: Carbetapentane
CAS Registry Number: 77-23-6
CAS Name: 1-Phenylcyclopentanecarboxylic acid 2-(2-diethylaminoethoxy)ethyl ester
Additional Names: 2-(diethylaminoethoxy)ethyl 1-phenyl-1-cyclopentanecarboxylate; 2-(diethylaminoethoxy)ethyl 1-phenylcyclopentyl-1-carboxylate; 1-phenylcyclopentane-1-carboxylic acid diethylaminoethoxyethyl ester; pentoxyverine; pentoxiverin
Molecular Formula: C20H31NO3
Molecular Weight: 333.47
Percent Composition: C 72.03%, H 9.37%, N 4.20%, O 14.39%
Literature References: Prepn: H. G. Morren, GB 753779; idem, US 2842585 (1956, 1958 both to Union Chimique Belge). Antispasmodic activity: D. Wellens, Arzneim.-Forsch. 17, 495 (1967). Clinical effect on lung function: E. Krieger, ibid. 22, 389 (1972).
Properties: bp0.01 165-170°.
Boiling point: bp0.01 165-170°
Derivative Type: Citrate
CAS Registry Number: 23142-01-0
Manufacturers' Codes: UCB-2543
Trademarks: Antees (Oriental); Calnathal; Carbetane (Toyo Jozo); Cossym (Egnaro); Fustpentane; Germapect (Thiemann); Pencal (Tatsumi); Sedotussin (UCB); Toclase (Pfizer); Tosnone (Nippon Shoji); Tuclase (Pfizer)
Molecular Formula: C20H31NO3.C6H8O7
Molecular Weight: 525.59
Percent Composition: C 59.41%, H 7.48%, N 2.66%, O 30.44%
Properties: Crystals, mp 93°. Freely sol in water, chloroform; sol in alcohol, acetone, ethyl acetate. Practically insol in ether, petr ether, benzene.
Melting point: mp 93°
Therap-Cat: Antitussive.
Keywords: Antitussive.
Carbetocin Carbic Anhydride Carbimazole Carbinoxamine Carbiphene

Pentoxyverine skeletal.svg
Systematic (IUPAC) name
2-[2-(diethylamino)ethoxy]ethyl 1-phenylcyclopentanecarboxylate
Clinical data
AHFS/ International Drug Names
MedlinePlus a606008
Pregnancy cat. No studies; contraindicated
Legal status OTC (US)
Routes Oral, rectal
Pharmacokinetic data
Metabolism Hepatic
Half-life 2.3 hours (oral), 3–3.5 hours (rectal)
Excretion Renal
CAS number 77-23-6 N
23142-01-0 (dihydrogen citrate)
1406-98-0 (tannate)
ATC code R05DB05
PubChem CID 2562
ChemSpider 2464 YesY
UNII 32C726X12W YesY
KEGG D08334 YesY
Chemical data
Formula C20H31NO3 
Mol. mass 333.465 g/mol
 N (what is this?)  (verify)

Pentoxyverine (rINN) or carbetapentane is an antitussive (cough suppressant) commonly used for cough associated with illnesses like common cold. It is sold over-the-counter in the United States as Solotuss,[1] or in combination with other medications, especially decongestants. One such product is Certuss, a combination of guaifenesin and pentoxyverine.[2]

The drug is available in the form of drops, suspensions and suppositories.[1][3]