Cardiotoxin

Title: Cardiotoxin
CAS Registry Number: 11061-96-4
Literature References: One of the toxic principles from cobra venom. Isoln: Sarkar, J. Indian Chem. Soc. 21, 227 (1947). A single peptide chain composed of 60 amino acid residues cross-linked by four disulfide bridges with leucine and asparagine at the N and C terminals respectively: Narita, Lee, Biochem. Biophys. Res. Commun. 41, 339 (1970). Causes irreversible depolarization of cell membrane and contraction of skeletal and smooth muscle. Shows direct lytic and marked cardiotoxic activities, potentiated by phospholipase A and prevented by polyanions (heparin, RNA, gangliosides). Pharmacology: Lee et al., Arch. Exp. Pathol. Pharmakol. 259, 360 (1968).
Carfentrazone-ethyl Carfimate Carglumic acid Cargutocin Carindacillin

Cardiotoxicity is the occurrence of heart electrophysiology dysfunction or muscle damage. The heart becomes weaker and is not as efficient in pumping and therefore circulating blood. Cardiotoxicity may be caused by chemotherapy[1] treatment, complications from anorexia nervosa, adverse effects of heavy metals intake, or an incorrectly administered drug such as bupivacaine.[citation needed]