Caroverine

Title: Caroverine
CAS Registry Number: 23465-76-1
CAS Name: 1-[2-(Diethylamino)ethyl]-3-[(4-methoxyphenyl)methyl]-2(1H)-quinoxalinone
Additional Names: 1-(diethylaminoethyl)-3-(p-methoxybenzyl)dihydro-2-quinoxalone
Trademarks: Spasmium (Donau)
Molecular Formula: C22H27N3O2
Molecular Weight: 365.47
Percent Composition: C 72.30%, H 7.45%, N 11.50%, O 8.76%
Literature References: Prepn: Zellner et al., US 3028384 (1962 to Donau-Pharm.). Polarographic study: P. Pflegel, Pharmazie 24, 667 (1969). Pharmacological study: F. Hahn et al., Arch. Int. Pharmacodyn. Ther. 199, 108 (1972).
Properties: Crystals from isopropyl alcohol, mp 69°. bp0.01 202°.
Melting point: mp 69°
Boiling point: bp0.01 202°
Derivative Type: Hydrochloride
Properties: Dec 188°.
Therap-Cat: Antispasmodic.
Keywords: Antispasmodic.
Caroxazone Carpaine Carpetimycins Carphenazine Carpipramine

Caroverine
Caroverine.png
Systematic (IUPAC) name
1-[2-(diethylamino)ethyl]- 3-(4-methoxybenzyl)quinoxalin- 2(1H)-one
Clinical data
Legal status Prescription only
Routes Oral
Identifiers
CAS number 23465-76-1
ATC code A03AX11
PubChem CID 65709
ChemSpider 59135 YesY
UNII XJ73B0K6KB YesY
Chemical data
Formula C22H27N3O2 
Mol. mass 365.47 g/mol
 YesY (what is this?)  (verify)

Caroverine (Spasmium, Spadon) is a drug used as a spasmolytic and otoneuroprotective (inner ear protective) agent in some countries.[1] It acts as an N-type calcium channel blocker, competitive AMPA receptor antagonist, and non-competitive NMDA receptor antagonist.[1] It also has potent antioxidant effects.[1][2]