Carticaine

Title: Carticaine
CAS Registry Number: 23964-58-1
CAS Name: 4-Methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester
Additional Names: 3-propylamino-a-propionylamino-2-carbomethoxy-4-methylthiophene; methyl 4-methyl-3-(2-propylaminopropionamido)thiophene-2-carboxylate; articaine
Molecular Formula: C13H20N2O3S
Molecular Weight: 284.37
Percent Composition: C 54.91%, H 7.09%, N 9.85%, O 16.88%, S 11.28%
Literature References: Prepn: H. Ruschig et al., ZA 6804265; eidem, US 3855243 (1969, 1974 both to Farbwerke Hoechst). Pharmacological studies: R. Muschaweck, R. Rippel, Prakt. Anaesth. 9, 135 (1974); H. Hofer et al., ibid. 157; A. Den Hertog, Eur. J. Pharmacol. 26, 175 (1974). Toxicity studies: C. Baeder et al., Prakt. Anaesth. 9, 147 (1974). Mechanism of action: U. Borchard, H. Drouin, Eur. J. Pharmacol. 62, 73 (1980). Review: H. Schneider, Schweiz. Monatsschr. Zahnheilkd. 86, 1188-1194 (1976).
Properties: bp0.3 162-167°.
Boiling point: bp0.3 162-167°
Derivative Type: Hydrochloride
CAS Registry Number: 23964-57-0
Manufacturers' Codes: HOE-045; HOE-40045
Trademarks: Ultracain (HMR)
Molecular Formula: C13H20N2O3S.HCl
Molecular Weight: 320.84
Percent Composition: C 48.67%, H 6.60%, N 8.73%, O 14.96%, S 9.99%, Cl 11.05%
Properties: White, fine crystals, mp 177-178°. LD50 i.v. in mice: 37 mg/kg (Muschaweck, Rippel).
Melting point: mp 177-178°
Toxicity data: LD50 i.v. in mice: 37 mg/kg (Muschaweck, Rippel)
Therap-Cat: Anesthetic (local).
Keywords: Anesthetic (Local).
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Articaine
Articaine.svg
Systematic (IUPAC) name
(RS)-methyl 4-methyl-3-(2-propylaminopropanoylamino)thiophene-2-carboxylate
Clinical data
AHFS/Drugs.com monograph
Pregnancy cat. C (US)
Legal status -only (US)
Routes Subcutaneous, submucosal, parenteral, epidural, intravenous
Pharmacokinetic data
Metabolism Liver, plasma
Half-life 30 min
Excretion Liver and unspecific plasma estearases[1]
Identifiers
CAS number 23964-57-0 N
ATC code N01BB08
PubChem CID 32170
ChemSpider 29837 YesY
UNII D3SQ406G9X YesY
KEGG D07468 N
ChEMBL CHEMBL1093 YesY
Synonyms Carticaine
Chemical data
Formula C13H20N2O3S 
Mol. mass 284.37 g/mol
320.836 g/mol (HCl)
 N (what is this?)  (verify)

Articaine is a dental local anesthetic. It is the most widely used local anesthetic in a number of European countries[2] and is available in many countries around the world.