Title: Cefazedone
CAS Registry Number: 56187-47-4
CAS Name: (6R,7R)-7-[[(3,5-Dichloro-4-oxo-1(4H)-pyridinyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Additional Names: 3-(5-methyl-1,3,4-thiadiazolyl-2-mercaptomethyl)-7-(3,5-dichloro-4-pyridon-1-ylacetamido)-3-cephem-4-carboxylic acid
Manufacturers' Codes: EMD-30087
Molecular Formula: C18H15Cl2N5O5S3
Molecular Weight: 548.44
Percent Composition: C 39.42%, H 2.76%, Cl 12.93%, N 12.77%, O 14.59%, S 17.54%
Literature References: Semi-synthetic cephalosporin antibiotic. Prepn: R. Gerike et al., DE 2345402; eidem, US 4153693 (1975, 1979 both to E. Merck, W. Ger.). See also eidem, DE 2621011, DE 2626026, DE 2627204 (all 1977 to E. Merck, W. Ger.), C.A. 88, 5093, 105383, 121213 (1978). Series of articles on prepn, in vitro and in vivo activity, kinetics, pharmacology, toxicology, and clinical trials: Arzneim.-Forsch. 29, 361-462 (1979). Toxicity data: M. von Eberstein et al., ibid. 424.
Properties: Crystals from acetonitrile.
Derivative Type: Sodium salt
CAS Registry Number: 63521-15-3
Trademarks: Refosporin (Merck KGaA)
Molecular Formula: C18H14Cl2N5NaO5S3
Molecular Weight: 570.43
Percent Composition: C 37.90%, H 2.47%, Cl 12.43%, N 12.28%, Na 4.03%, O 14.02%, S 16.86%
Properties: LD50 in mice, rats, rabbits, dogs (mg/kg): 6800, 4225, 3200, 3000 i.v. (von Eberstein).
Toxicity data: LD50 in mice, rats, rabbits, dogs (mg/kg): 6800, 4225, 3200, 3000 i.v. (von Eberstein)
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephalosporins.
Cefazolin Cefbuperazone Cefcapene Pivoxil Cefclidin Cefdinir

Systematic (IUPAC) name
oct-2-ene-2-carboxylic acid
Clinical data
Legal status  ?
CAS number 56187-47-4
ATC code J01DB06
PubChem CID 71736
ChemSpider 64780 YesY
UNII 7Y86X0D799 YesY
KEGG D07237 YesY
Chemical data
Formula C18H15Cl2N5O5S3 
Mol. mass 548.446 g/mol
 YesY (what is this?)  (verify)

Cefazedone is a cephalosporin antibiotic.