Ceforanide

Title: Ceforanide
CAS Registry Number: 60925-61-3
CAS Name: (6R,7R)-7-[[[2-(Aminomethyl)phenyl]acetyl]amino]-3-[[[1-(carboxymethyl)-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Additional Names: (6R,7R)-7-[2-(a-amino-o-tolyl)acetamido]-3-[[[1-(carboxymethyl)-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7-[o-(aminomethyl)phenylacetamido]-3-[[[1-(carboxymethyl)-1H-tetrazol-5-yl]thio]methyl]-3-cephem-4-carboxylic acid
Manufacturers' Codes: BL-S786
Molecular Formula: C20H21N7O6S2
Molecular Weight: 519.55
Percent Composition: C 46.24%, H 4.07%, N 18.87%, O 18.48%, S 12.34%
Literature References: Injectable, semi-synthetic cephalosporin antibiotic. Prepn: M. A. Kaplan et al., DE 2538804; W. J. Gottstein et al., US 4100346, US 4172196 and US 4182863 (1976, 1978, 1979, 1980 all to Bristol-Myers); W. J. Gottstein et al., J. Antibiot. 29, 1226 (1976). Laboratory evaluation: F. Leitner et al., Antimicrob. Agents Chemother. 10, 426 (1976). In vitro susceptibility comparisons: R. N. Jones et al., J. Antibiot. 30, 576, 583 (1977). Comparative tissue distribution: F. H. Lee et al., Antimicrob. Agents Chemother. 19, 625 (1981). Pharmacokinetics: E. H. Estey et al., Clin. Pharmacol. Ther. 30, 396 (1981); S. S. Hawkins et al., ibid. 468. Clinical study: R. J. Wallace et al., Antimicrob. Agents Chemother. 20, 648 (1981).
Properties: White solid, mp >150° (dec).
Melting point: mp >150° (dec)
Derivative Type: L-Lysine salt
CAS Registry Number: 63767-79-3
Trademarks: Precef (BMS)
Molecular Formula: C20H21N7O6S2.C6H14N2O2
Molecular Weight: 665.74
Percent Composition: C 46.91%, H 5.30%, N 18.94%, O 19.23%, S 9.63%
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephalosporins.
Cefoselis Cefotetan Cefotiam Cefoxitin Cefozopran

Ceforanide
Ceforanide.svg
Systematic (IUPAC) name
(6R,7R)-7-{[2-[2-(aminomethyl)phenyl]acetyl]amino}-3-
{[1-(carboxymethyl)tetrazol-5-yl]sulfanylmethyl}-8-oxo-
5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Clinical data
AHFS/Drugs.com International Drug Names
Legal status  ?
Routes Intramuscular
Pharmacokinetic data
Protein binding 80.6%
Metabolism Nil
Half-life 2.6 to 2.98 hours
Excretion Renal
Identifiers
CAS number 60925-61-3 YesY
ATC code J01DC11
PubChem CID 43507
DrugBank DB00923
ChemSpider 39656 YesY
UNII 8M1YF8951V YesY
KEGG D00259 YesY
ChEBI CHEBI:3495 YesY
ChEMBL CHEMBL1201046 N
NIAID ChemDB 007642
Chemical data
Formula C20H21N7O6S2 
Mol. mass 519.556 g/mol
 N (what is this?)  (verify)

Ceforanide is a second-generation cephalosporin antibiotic.