Cefquinome

Title: Cefquinome
CAS Registry Number: 84957-30-2
CAS Name: 1-[[(6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-5,6,7,8-tetrahydroquinolinium inner salt
Manufacturers' Codes: HOE-111
Molecular Formula: C23H24N6O5S2
Molecular Weight: 528.60
Percent Composition: C 52.26%, H 4.58%, N 15.90%, O 15.13%, S 12.13%
Literature References: Broad-spectrum fourth generation injectable aminothiazolyl cephalosporin. Prepn: BE 893163; R. Lattrell et al., US 5071979 (1982, 1991 both to Hoechst); R. F. Brown et al., J. Med. Chem. 33, 2114 (1990). Antibacterial spectrum and pharmacokinetics in animals: M. Limbert et al., Antimicrob. Agents Chemother. 35, 14 (1991). In vitro activity against bovine bacterial isolates: A. Böttner et al., J. Vet. Med. B 42, 377 (1995). Efficacy in the treatment of mastitis in dairy cows: N. Y. Shpigel et al., J. Dairy Sci. 80, 318 (1997).
Derivative Type: Sulfate
CAS Registry Number: 118443-89-3
Manufacturers' Codes: HR-111V
Trademarks: Cobactan (Intervet)
Molecular Formula: C23H24N6O5S2.H2SO4
Molecular Weight: 626.68
Percent Composition: C 44.08%, H 4.18%, N 13.41%, O 22.98%, S 15.35%
Therap-Cat-Vet: Antibacterial.
Cefroxadine Cefsulodin Cefteram Ceftezole Ceftibuten

Cefquinome
Cefquinome.svg
Systematic (IUPAC) name
1-[[(6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)-
(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-
5-thia-1-azabicyclo[4.2.0-oct-2-en-3-yl]methyl]-
5,6,7,8-tetrahydroquinolinium inner salt
Clinical data
Legal status Rx-only, Unscheduled (US)
Pharmacokinetic data
Bioavailability 87%
Protein binding <5%
Half-life 2½ hours
Excretion Renal, unchanged
Identifiers
CAS number 84957-30-2 YesY
ATCvet code QG51AA07 QJ01DE90 QJ51DE90
ChemSpider 16736863 YesY
UNII Z74S078CWP YesY
KEGG D07652 YesY
Chemical data
Formula C23H24N6O5S2 
Mol. mass 528.60 g/mol
 YesY (what is this?)  (verify)

Cefquinome is a fourth generation cephalosporin with pharmacological and antibacterial properties valuable in the treatment of coliform mastitis and other infections. It is only used in veterinary applications.