Cephalonium

Title: Cephalonium
CAS Registry Number: 5575-21-3
CAS Name: 4-(Aminocarbonyl)-1-[[(6R,7R)-2-carboxy-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinium inner salt
Additional Names: cefalonium; 2-thienylmethyl isonicotinamide cephalosporin CA
Trademarks: Cepravin Dry Cow (Schering-Plough)
Molecular Formula: C20H18N4O5S2
Molecular Weight: 458.51
Percent Composition: C 52.39%, H 3.96%, N 12.22%, O 17.45%, S 13.99%
Literature References: Cephalosporin antibiotic. Prepn: E. H. Flynn, GB 1067644 (1967 to Lilly); and antibacterial activity: J. L. Spencer et al., Antimicrob. Agents Chemother. 1966, 573. Determn in milk samples: J. E. Hillerton et al., J. Dairy Sci. 82, 704 (1999). Prophylactic use in dry udder infections: R. Curtis et al., Vet. Rec. 100, 557 (1977); in mastitis: J. H. Williamson et al., N. Z. Vet. J. 43, 228 (1995); in combination with a teat sealer: M. W. Woolford et al., ibid. 46, 12 (1998).
Properties: Crystals from hot water, mp 147-150° (dec). uv max: 233, 262 nm (e 16650, 13550). pKa: 3.3.
Melting point: mp 147-150° (dec)
pKa: pKa: 3.3
Absorption maximum: uv max: 233, 262 nm (e 16650, 13550)
Therap-Cat-Vet: Prophylactic use in mastitis and dry udder therapy.
Cephaloridine Cephalosporin C Cephalosporin P1 Cephamycins Cephapirin Sodium