Cephalosporin P1

Title: Cephalosporin P1
CAS Registry Number: 28393-42-2
CAS Name: (3a,4a,6a,7b,8a,9b,13a,14b,16b,17Z)-6,16-Bis(acetyloxy)-3,7-dihydroxy-29-nordammara-17(20),24-dien-21-oic acid
Molecular Formula: C33H50O8
Molecular Weight: 574.75
Percent Composition: C 68.96%, H 8.77%, O 22.27%
Literature References: Antibiotic substance produced by a Cephalosporium sp. cultivated from the sea near Sardinia. Crude cephalosporin P contains at least 5 components: P1, P2, P3, P4, P5, the major active substance being cephalosporin P1. Isoln: Burton, Abraham, Biochem. J. 50, 168 (1951). Structure: Baird et al., Proc. Chem. Soc. London 1961, 257; Halsall et al., ibid. 1963, 16; Melera, Experientia 19, 565 (1963); Halsall et al., Chem. Commun. 1966, 685.
Properties: Orthorhombic crystals from 50% aq ethanol, C33H50O8.H2O.½C2H5OH. mp 147°. [a]D20 +28° (c = 2.7 in chloroform). uv max: 211 nm (e 9140). Readily sol in chloroform and ethanol; sparingly sol in hexane and water.
Melting point: mp 147°
Optical Rotation: [a]D20 +28° (c = 2.7 in chloroform)
Absorption maximum: uv max: 211 nm (e 9140)
Cephamycins Cephapirin Sodium Cepharanthine Cephradine Ceresin