Cephamycins

Title: Cephamycins
Literature References: A family of b-lactam antibiotics produced by various Streptomyces species. Detection and production: Stapley et al., Antimicrob. Agents Chemother. 2, 122 (1972). Chemical characterization: Miller et al., ibid. 132. Cephamycins A, B, and C have been isolated, the latter being identical to a Streptomyces clavuligerus metabolite: Nagarajan et al., J. Am. Chem. Soc. 93, 2308 (1971). Structures: Albers-Schoenberg et al., Tetrahedron Lett. 1972, 2911. Antibacterial activity studies: Miller et al., Antimicrob. Agents Chemother. 2, 281, 287 (1972); Daoust et al., ibid. 3, 254 (1973). Review of syntheses: T. Hiraoka et al., Heterocycles 8, 719 (1977).
Cephapirin Sodium Cepharanthine Cephradine Ceresin Ceric Fluoride

Cefoxitin
Cefotetan
Cefmetazole

Cephamycins are a group of beta-lactam antibiotics. They are very similar to cephalosporins, and the cephamycins are sometimes classified as cephalosporins.

Like cephalosporins, cephamycins are based upon the cephem nucleus. Unlike most cephalosporins, cephamycins are a very efficacious antibiotic against anaerobic microbes.

Cephamycins were originally produced by Streptomyces, but synthetic ones have been produced as well.

Cephamycins possess a methoxy group at the 7-alpha position.[1]

In addition, cephamycins have been shown to be stable against extended-spectrum beta-lactamase (ESBL) producing organisms although their use in clinical practice is lacking for this indication.