Certolizumab Pegol

Title: Certolizumab Pegol
CAS Registry Number: 428863-50-7; 339184-10-0 (Fab fragment)
CAS Name: Pegylated anti-(human tumor necrosis factor a) Fab¢ fragment (human-mouse monoclonal CDP870 heavy chain) immunoglobulin disulfide with human-mouse monoclonal CDP870 light chain
Manufacturers' Codes: CDP-870
Trademarks: Cimzia (UCB)
Literature References: Recombinant humanized monoclonal antibody Fab fragment linked to polyethylene glycol, q.v.; directed against tumor necrosis factor a (TNF-a). Prepn: D. S. Athwal et al., WO 0194585; eidem, US 02151682 (2001, 2002 both to Celltech). Clinical evaluation in rheumatoid arthritis: E. H. S. Choy et al., Rheumatology 41, 1133 (2002); in Crohn's disease: S. Schreiber et al., Gastroenterology 129, 807 (2005). Review of development and therapeutic potential: S. Rose-John, H. Schooltink, Curr. Opin. Invest. Drugs 4, 588-592 (2003); of clinical evaluation in rheumatoid arthritis: V. V. Kaushik, R. J. Moots, Expert Opin. Biol. Ther. 5, 601-606 (2005).
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Biological Response Modifier).
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