Cetylpyridinium Chloride

Title: Cetylpyridinium Chloride
CAS Registry Number: 123-03-5
CAS Name: 1-Hexadecylpyridinium chloride
Trademarks: Ceepryn (J. B. Williams); Medilave (Farillon); Merocet (HMR); Pristacin; Pyrisept
Molecular Formula: C21H38ClN
Molecular Weight: 339.99
Percent Composition: C 74.19%, H 11.27%, Cl 10.43%, N 4.12%
Literature References: Pharmacology and toxicology: J. Pharmacol. Exp. Ther. 74, 401 (1942). Review of early literature: C. L. Huyck, Am. J. Pharm. 116, 50 (1944). Toxicity data: J. W. Nelson, S. C. Lyster, J. Am. Pharm. Assoc. 35, 89 (1946).
Derivative Type: Monohydrate
CAS Registry Number: 6004-24-6
Trademarks: Dobendan (Cassella-med); Halset (Strohschein)
Properties: White powder, mp 77-83°. Freely sol in water, alcohol, chloroform; very slightly sol in benzene, ether. pH (1% aq soln): 6.0 to 7.0. Surface tension (25°): 43 dyn/cm (0.1% aq soln); 41 dyn/cm (1.0%); 38 dyn/cm (10%). LD50 in rats (mg/kg): 250 s.c.; 6 i.p.; 30 i.v.; 200 orally (Nelson, Lyster).
Melting point: mp 77-83°
Toxicity data: LD50 in rats (mg/kg): 250 s.c.; 6 i.p.; 30 i.v.; 200 orally (Nelson, Lyster)
Use: Pharmaceutic aid (preservative).
Therap-Cat: Antiseptic; disinfectant.
Therap-Cat-Vet: Topical antiseptic; disinfectant.
Keywords: Antiseptic/Disinfectant; Quaternary Ammonium Compounds.
Cevadine Cevine Chalcomycin Chalcone Chamazulene

Cetylpyridinium chloride
Cetylpyridiniumchlorid.svg
Identifiers
CAS number 123-03-5 YesY, 6004-24-6 (monohydrate)
PubChem 31239
ChemSpider 28979 YesY
UNII 6BR7T22E2S YesY
ChEBI CHEBI:32915 YesY
ChEMBL CHEMBL34833 YesY
ATC code B05CA01, D08AJ03,
D09AA07 (dressing), R02AA06
Beilstein Reference 3578606
Jmol-3D images Image 1
Properties
Molecular formula C21H38ClN
Molar mass 339.99 g mol−1
Appearance solid
Melting point 77 °C; 171 °F; 350 K
Hazards
LD50 36 mg/kg (rabbit, iv)[1]
400 mg/kg (rabbit, oral)[1]
6 mg/kg (rat, ip)[1]
30 mg/kg (rat, iv)[1]
200 mg/kg (rat, oral)[1]
250 mg/kg (rat, sc)[1]
10 mg/kg (mouse, ip)[1]
108 mg/kg (mouse, oral)[1]
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Cetylpyridinium chloride (CPC) is a cationic quaternary ammonium compound used in some types of mouthwashes, toothpastes, lozenges, throat sprays, breath sprays, and nasal sprays. It is an antiseptic that kills bacteria and other microorganisms. It has been shown to be effective in preventing dental plaque and reducing gingivitis.[2][3] It has also been used as an ingredient in certain pesticides. Cetylpyridinium chloride may cause brown stains between the teeth and on the surface of teeth.[4][5] However, these stains can be easily removed by a dental hygienist during a routine check-up.[4][5]