Chloral Betaine

Title: Chloral Betaine
CAS Registry Number: 2218-68-0
CAS Name: 1-Carboxy-N,N,N-trimethylmethanaminium inner salt compd with 2,2,2-trichloro-1,1-ethanediol (1:1)
Trademarks: Beta-Chlor (Mead Johnson); Somilan (BDH)
Molecular Formula: C7H14Cl3NO4
Molecular Weight: 282.55
Percent Composition: C 29.76%, H 4.99%, Cl 37.64%, N 4.96%, O 22.65%
Literature References: Prepd by warming betaine hydrate and chloral hydrate: Petrow et al., GB 874246 (1959 to British Drug Houses).
Properties: Prisms from water, mp 122.5-124.5°.
Melting point: mp 122.5-124.5°
NOTE: This is a controlled substance (depressant): 21 CFR, 1308.14.
Therap-Cat: Sedative, hypnotic.
Keywords: Sedative/Hypnotic; Chloral Derivatives.
Status: This monograph has been retired and is no longer subject to revision or update.
Chloral Formamide Chloramben Chlorambucil Chloramine-B Chloramine-T

Chloral betaine is a sleeping tablet or sedative which the body converts to chloral hydrate, which is further metabolized to trichloroethanol, which is responsible for the majority of its effects. Like other drugs of this type chloral betaine is addictive, a small proportion of users who take the drug develop serious or unpleasant side effects. Due to its metabolism into chloral hydrate, it likely exhibits relatively high toxicity compared to other sedatives.