Chlormerodrin

Title: Chlormerodrin
CAS Registry Number: 62-37-3
CAS Name: [3-[(Aminocarbonyl)amino]-2-methoxypropyl]chloromercury
Additional Names: 1-[3-(chloromercuri)-2-methoxypropyl]urea; chlormeroprin
Trademarks: Katonil (Kali-Chemie); Mercoral; Diurone; Mercloran (Parke-Davis); Percapyl; Merilid; Oricur
Molecular Formula: C5H11ClHgN2O2
Molecular Weight: 367.20
Percent Composition: C 16.35%, H 3.02%, Cl 9.65%, Hg 54.63%, N 7.63%, O 8.71%
Literature References: Prepn: R. L. Rowland, US 2635982 (1953 to Lakeside); R. L. Rowland et al., J. Am. Chem. Soc. 72, 3595 (1950); E. L. Foreman, US 2635983 (1953 to Lakeside). Toxicity data: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).
Properties: Crystals from ethanol, mp 152-153°. Bitter, metallic taste. Stable to light and air. Soly in water, methanol: both 1.1 g/100 ml; in ethanol: 0.56 g/100 ml. Sparingly sol in chloroform. Freely sol in alkaline solns. pH of a 0.5% aq soln 4.3-5.0. LD50 orally in rats: ~82 mg/kg (Goldenthal).
Melting point: mp 152-153°
Toxicity data: LD50 orally in rats: ~82 mg/kg (Goldenthal)
Therap-Cat: Diuretic.
Therap-Cat-Vet: Diuretic.
Keywords: Diuretic; Organomercurials.
Chlormezanone Chlormidazole Chlornitrofen Chloroacetaldehyde Chloroacetamide

Chlormerodrin skeletal.svg
Systematic (IUPAC) name
[3-(Carbamoylamino)-2-methoxypropyl](chloro)mercury
Clinical data
AHFS/Drugs.com Medical Encyclopedia
Legal status Withdrawn (US)
Identifiers
CAS number 62-37-3
ATC code None
PubChem CID 25210
DrugBank DB00534
ChemSpider 2615
ChEBI CHEBI:59445
Chemical data
Formula C5H11ClHgN2O2 
Mol. mass 367.196 g/mol

Chlormerodrin is a diuretic that was once used to treat patients with heart failure, but is no longer used in the United States.[1]