Chlorotoxin

Title: Chlorotoxin
CAS Registry Number: 163515-35-3
Additional Names: ClTx; Ctx
Literature References: Small neurotoxic peptide (36 amino acids) isolated from the venom of the scorpion, Leiurus quinquestriatus characterized by 4 disulfide linkages. Specific blocker of small conductance chloride channels. Isoln, purification, and characterization: J. A. DeBin et al., Am. J. Physiol. 264, C361 (1993). Solid phase synthesis: J. Najib et al., 3rd Int. Symp. 1993 Innovation Perspect. Solid Phase Synth. Collect. Pap. 1994, 615. NMR and secondary structure: G. Lippens et al., ibid. 583; and solution structure: eidem, Biochemistry 34, 13 (1995). Identification of chloride channel in gliomas: N. Ullrich et al., Neuroscience 83, 1161 (1998); inhibition of glioma cell invasion: J. Deshane et al., J. Biol. Chem. 278, 4135 (2003). Use in cell topography: G. Tobasnick, A. S. G. Curtis, Eur. Cells Materials 2, 49 (2001).
Use: Biochemical probe for voltage-gated chloride channels.
Chloroxine Chloroxylenol Chlorozotocin Chlorphenesin Chlorphenesin Carbamate

Chlorotoxin
Chlorotoxin.png
Identifiers
CAS number 163515-35-3 N
Properties
Molecular formula C158H249N53O47S11
Molar mass 3,995.71 g mol−1
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Chlorotoxin is a 36-amino acid peptide found in the venom of the deathstalker scorpion (Leiurus quinquestriatus) which blocks small-conductance chloride channels.[1] The fact that chlorotoxin binds preferentially to glioma cells has allowed the development of new methods, that still are under investigation, for the treatment and diagnosis of several types of cancer.[2]