Cicletanine

Title: Cicletanine
CAS Registry Number: 89943-82-8
CAS Name: 3-(4-Chlorophenyl)-1,3-dihydro-6-methylfuro[3,4-c]pyridin-7-ol
Additional Names: 1,3-dihydro-3-(4-chlorophenyl)-7-hydroxy-6-methylfuro[3,4-c]pyridine; cicletanide; cycletanide
Molecular Formula: C14H12ClNO2
Molecular Weight: 261.70
Percent Composition: C 64.25%, H 4.62%, Cl 13.55%, N 5.35%, O 12.23%
Literature References: Furopyridine derivative with antihypertensive and diuretic properties. Prepn: A. Esanu, BE 891797; idem, US 4383998 (1982, 1983 both to Soc. Conseils Recher. Sci.). Studies on mechanism of action: P. Braquet et al., Lancet 1, 1218 (1983); G. R. Elliott et al., Thromb. Res. 33, 549 (1984). Cardiovascular pharmacology in dogs: R. Jouve et al., J. Cardiovasc. Pharmacol. 8, 208 (1986). In vitro comparison of antihistaminic activity of isomers: P. Schoeffter et al., Eur. J. Pharmacol. 136, 235 (1987). HPLC determn in biological fluids: G. Cuisinaud et al., J. Chromatogr. 341, 97 (1985). Effect on human prostaglandin metabolism: P. Guinot, J. C. Frölich, Arzneim.-Forsch. 35, 1714 (1985). Effect on potassium ion transport in hypertensive patients: R. Garay et al., J. Hypertens. 4, Suppl. 5, S208 (1986). Pharmacokinetics in humans: J. M. Lize et al., Therapie 42, 399 (1987).
Derivative Type: Hydrochloride
CAS Registry Number: 82747-56-6
Manufacturers' Codes: BN-1270
Trademarks: Coverine (Astier); Justar (Intersan); Secletan (Ipsen); Tenstaten (Ipsen)
Molecular Formula: C14H12ClNO2.HCl
Molecular Weight: 298.16
Percent Composition: C 56.40%, H 4.39%, Cl 23.78%, N 4.70%, O 10.73%
Properties: White crystals, mp 219-228°. Insol in water.
Melting point: mp 219-228°
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive.
Ciclonicate Ciclopirox Ciclosidomine Cicrotoic Acid Cicutoxin

Cicletanine
Cycletanide.png
Systematic (IUPAC) name
3-(4-Chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol
Clinical data
AHFS/Drugs.com International Drug Names
Legal status  ?
Routes Oral
Pharmacokinetic data
Protein binding 97.3%
Half-life 7.9 h
Identifiers
CAS number 89943-82-8
ATC code C03BX03
PubChem CID 54910
ChemSpider 49583 YesY
UNII CHG7QC509W YesY
KEGG D03487 YesY
ChEMBL CHEMBL191886 YesY
Chemical data
Formula C14H12ClNO2 
Mol. mass 261.703 g/mol
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Cicletanine is a furopyridine low-ceiling diuretic drug, usually used in the treatment of hypertension.[1] The drug is manufactured by Ipsen and marketed by Recordati (in France) under the trade name Tenstaten.

It appears to be more potent in salt-sensitive hypertension.[2]