Cinmetacin

Title: Cinmetacin
CAS Registry Number: 20168-99-4
CAS Name: 5-Methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propenyl)-1H-indole-3-acetic acid
Additional Names: 1-cinnamoyl-5-methoxy-2-methylindole-3-acetic acid; 1-cinnamoyl-2-methyl-5-methoxy-3-indolylacetic acid
Trademarks: Cindomet (Chiesi); Indolacin (Sumitomo)
Molecular Formula: C21H19NO4
Molecular Weight: 349.38
Percent Composition: C 72.19%, H 5.48%, N 4.01%, O 18.32%
Literature References: Prepn: H. Yamamoto, M. Nakao, ZA 6702683; eidem, US 3576800 (1968, 1971 both to Sumitomo); eidem, J. Med. Chem. 12, 176 (1969). Pharmacology: T. Komatsu et al., Arzneim.-Forsch. 23, 1690 (1973).
Properties: Yellow crystals from acetone-water, mp 170-172°; also reported as mp 164-165°. LD50 in mice, rats (mg/kg): 360, 590 i.p.; 750, 1020 orally (Komatsu).
Melting point: mp 170-172°; mp 164-165°
Toxicity data: LD50 in mice, rats (mg/kg): 360, 590 i.p.; 750, 1020 orally (Komatsu)
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives.
Status: This monograph has been retired and is no longer subject to revision or update.
Cinmethylin Cinnabarine Cinnamaldehyde Cinnamedrine Cinnamic Acid