Title: Clevidipine
CAS Registry Number: 167221-71-8
CAS Name: 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl (1-oxybutoxy)methyl ester
Additional Names: butyroxymethyl methyl 4-(2¢,3¢-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Trademarks: Clevelox (AstraZeneca)
Molecular Formula: C21H23Cl2NO6
Molecular Weight: 456.32
Percent Composition: C 55.27%, H 5.08%, Cl 15.54%, N 3.07%, O 21.04%
Literature References: Ultrashort-acting dihydropyridine calcium channel antagonist. Prepn: K. H. Andersson et al., WO 9512578; eidem, US 5856346 (1995, 1999 both to Astra). Improved prepn: A. Mattson et al., WO 0031035 (2000 to AstraZeneca). Capillary GC/MS determn in whole blood: C. Fakt, H. Stenhoff, J. Chromatogr. B 723, 211 (1999). Clinical pharmacokinetics: H. Ericsson et al., Br. J. Clin. Pharmacol. 47, 531 (1999); and pulmonary extraction during cardiopulmonary bypass: A. Vuylsteke et al., Br. J. Anaesth. 85, 683 (2000). Clinical evaluation in hypertension in postoperative cardiac surgical patients: N. Kieler-Jensen et al., Acta Anaesthesiol. Scand. 44, 186 (2000); J. M. Bailey et al., Anesthesiology 96, 1086 (2002). Review of pharmacology and clinical development: M. Nordlander et al., Cardiovasc. Drug Rev. 22, 227-250 (2004).
Properties: Crystals from diisopropylether, mp 136.2-138.5°. Soly in water: 0.1 mg/ml.
Melting point: mp 136.2-138.5°
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Dihydropyridine Derivatives; Calcium Channel Blocker; Dihydropyridine Derivatives.
Clidanac Clidinium Bromide Clinafloxacin Clinofibrate Clinprost

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Systematic (IUPAC) name
O3-(butanoyloxymethyl) O5-methyl (4R)- 4-(2,3-dichlorophenyl)-2,6-dimethyl- 1,4-dihydropyridine-3,5-dicarboxylate
Clinical data
Trade names Cleviprex
AHFS/ Consumer Drug Information
Licence data US FDA:link
Pregnancy cat. C (US)
Legal status -only (US)
Routes Intravenous
Pharmacokinetic data
Bioavailability -
Protein binding >99.5%
Metabolism blood and tissue esterases
Half-life 1 minute
Excretion urine 63-74%, feces 7-22%
CAS number 166432-28-6
ATC code C08CA16
PubChem CID 193993
ChemSpider 168334
Chemical data
Formula C21H23Cl2NO6 
Mol. mass 456.316 g/mol

Clevidipine (INN, trade name Cleviprex) is a dihydropyridine calcium channel blocker indicated for the reduction of blood pressure when oral therapy is not feasible or not desirable.

It was approved by the United States Food and Drug Administration on August 1, 2008.