Clinofibrate

Title: Clinofibrate
CAS Registry Number: 30299-08-2
CAS Name: 2,2¢-[Cyclohexylidenebis(4,1-phenyleneoxy)]bis[2-methylbutanoic acid]
Additional Names: 2,2¢-(4,4¢-cyclohexylidenediphenoxy)-2,2¢-dimethyldibutyric acid
Manufacturers' Codes: S-8527
Trademarks: Lipoclin (Sumitomo)
Molecular Formula: C28H36O6
Molecular Weight: 468.58
Percent Composition: C 71.77%, H 7.74%, O 20.49%
Literature References: Anti-atherosclerosis agent, related structurally to clofibrate, q.v. Prepn: Y. Nakamura et al., DE 2017331; eidem, US 3716583 (1970, 1973 both to Sumitomo). Hypolipidemic activity: K. Toki et al., Atherosclerosis 18, 101 (1973); K. Suzuki et al., Jpn. J. Pharmacol. 24, 407 (1974), C.A. 82, 25821z (1975). Effect on cholesterol and lipoprotein metabolism in rats: K. Suzuki, Biochem. Pharmacol. 25, 325 (1976). General pharmacology: H. Nakatani et al., Oyo Yakuri 16, 687 (1978), C.A. 90, 145808 (1979).
Properties: Off-white powder, mp 143-146° (dec). Sol in methanol, ethanol, acetone, chloroform, glacial acetic acid. Slightly sol in CCl4. Practically insol in water.
Melting point: mp 143-146° (dec)
Therap-Cat: Antilipemic.
Keywords: Antilipemic; Fibrates.
Clinprost Clioxanide Clobazam Clobenfurol Clobenoside

Clinofibrate
Clinofibrate.svg
Systematic (IUPAC) name
2-(4-{1-[4-(1-carboxy-1-methylpropoxy)phenyl]cyclohexyl}phenoxy)-2-methylbutanoic acid
Clinical data
AHFS/Drugs.com International Drug Names
Legal status Prescription only
Routes Oral
Identifiers
CAS number 30299-08-2 YesY
ATC code None
PubChem CID 2787
ChemSpider 21613360 N
UNII 0374EZJ8CU YesY
KEGG D01300 YesY
Chemical data
Formula C28H36O6 
Mol. mass 468.58 g/mol
 N (what is this?)  (verify)

Clinofibrate (INN, trade name Lipoclin) is a fibrate.