Clioxanide

Title: Clioxanide
CAS Registry Number: 14437-41-3
CAS Name: 2-(Acetyloxy)-N-(4-chlorophenyl)-3,5-diiodobenzamide
Additional Names: 4¢-chloro-3,5-diiodosalicylanilide acetate; acetoxy-4¢-chloro-3,5-diiodobenzanilide
Manufacturers' Codes: CI-633; SYD-230
Trademarks: Tremerad (Parke-Davis)
Molecular Formula: C15H10ClI2NO3
Molecular Weight: 541.51
Percent Composition: C 33.27%, H 1.86%, Cl 6.55%, I 46.87%, N 2.59%, O 8.86%
Literature References: Prepn from 4¢-chloro-3,5-diiodosalicylanilide: A. Campbell et al., Experientia 23, 992 (1967); NL 6604303 (1966 to Parke, Davis), C.A. 66, 55247d (1967), corresp to GB 1070516. Anthelmintic activity: Presidente et al., Am. J. Vet. Res. 33, 1593 (1972).
Properties: Needles from aq DMF or acetone, mp 215-216°. uv max (methanol): 262 nm. LD50 in sheep (mg/kg): ~420 by rumenal route; 1600 by abomasal route (Campbell).
Melting point: mp 215-216°
Absorption maximum: uv max (methanol): 262 nm
Toxicity data: LD50 in sheep (mg/kg): ~420 by rumenal route; 1600 by abomasal route (Campbell)
Therap-Cat-Vet: Anthelmintic (Trematodes).
Status: This monograph has been retired and is no longer subject to revision or update.
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