Clobetasone

Title: Clobetasone
CAS Registry Number: 54063-32-0
CAS Name: (16b)-21-Chloro-9-fluoro-17-hydroxy-16-methylpregna-1,4-diene-3,11,20-trione
Additional Names: 21-chloro-11-dehydrobetamethasone
Molecular Formula: C22H26ClFO4
Molecular Weight: 408.89
Percent Composition: C 64.62%, H 6.41%, Cl 8.67%, F 4.65%, O 15.65%
Literature References: Prepn: Elks et al., DE 1902340; eidem, US 3721687 (1969, l973, both to Glaxo). Activity: Munro, Wilson, Br. Med. J. 3, 626 (1975). Radioimmunoassay: W. A. Webb, R. V. Brooks, Acta Endocrinol. Suppl. 212, 203 (1977). Toxicology: J. Tamura et al., J. Toxicol. Sci. 5, 45, 177 (1980). Comparative clinical studies: A. Lassus, Curr. Med. Res. Opin. 6, 165 (1979); T. Fredriksson, K. Nordin, ibid. 322. Clinical evaluation of ophthalmic form: D. Lloyd-Jones et al., Br. J. Ophthalmol. 65, 641 (1981); L. A. Eilon, S. R. Walker, ibid. 644; K. R. Wilhelmus et al., ibid. 699.
Derivative Type: 17-Butyrate
CAS Registry Number: 25122-57-0
Manufacturers' Codes: GR-2/1214
Trademarks: Emovate (GSK); Eumovate (GSK)
Molecular Formula: C26H32ClFO5
Molecular Weight: 478.98
Percent Composition: C 65.20%, H 6.73%, Cl 7.40%, F 3.97%, O 16.70%
Properties: Crystals from methanol, mp 90-100°.
Melting point: mp 90-100°
Therap-Cat: Glucocorticoid; anti-inflammatory.
Keywords: Glucocorticoid.
Clobuzarit Clocinizine Cloconazole Clocortolone Clodinafop-Propargyl

Clobetasone
Clobetasone.png
Systematic (IUPAC) name
(1R,2S,10S,11S,13S,14R,15S)-14-(2-chloroacetyl)-1-fluoro-14-hydroxy-2,13,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-diene-5,17-dione
Clinical data
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Legal status  ?
Routes topical
Identifiers
CAS number 54063-32-0
ATC code D07AB01 S01BA09
PubChem CID 71387
ChemSpider 64482 YesY
UNII LT69WY1J6D YesY
KEGG D07717 YesY
Synonyms (8S,9R,10S,13S,14S,16S,17R)-17-(2-Chloroacetyl)-9-fluoro-17-hydroxy-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthrene-3,11-dione
Chemical data
Formula C22H26ClFO4 
Mol. mass 408.891
 YesY (what is this?)  (verify)

Clobetasone (INN[1]) is a corticosteroid used in dermatology, for treating such skin inflammation as seen in eczema, psoriasis and other forms of dermatitis, and ophthalmology.

It is available as clobetasone butyrate under the brand name Eumovate[2] or Trimovate,[3] both manufactured by GlaxoSmithKline.

As Trimovate, it also contains Oxytetracycline, an antibiotic, and nystatin, an antifungal.[4][5]