Title: Clocortolone
CAS Registry Number: 4828-27-7
CAS Name: (6a,11b,16a)-9-Chloro-6-fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
Additional Names: 9-chloro-6a-fluoro-16a-methyl-1,4-pregnadiene-11b,21-diol-3,20-dione
Molecular Formula: C22H28ClFO4
Molecular Weight: 410.91
Percent Composition: C 64.30%, H 6.87%, Cl 8.63%, F 4.62%, O 15.57%
Literature References: Prepn: NL 6412708; E. K. Kaspar, R. Philippson, DE 2011559; eidem, US 3729495 (1965, 1971, 1973 all to Schering AG). Clinical trials: Wortmann, Wien. Med. Wochenschr. 122, 701 (1972); Baumann, Praxis 61, 536 (1972).
Properties: Crystals from methanol-methylene chloride, mp 254° (dec).
Melting point: mp 254° (dec)
Derivative Type: 21-Acetate
CAS Registry Number: 4258-85-9
Manufacturers' Codes: SH-818
Molecular Formula: C24H30ClFO5
Molecular Weight: 452.94
Percent Composition: C 63.64%, H 6.68%, Cl 7.83%, F 4.19%, O 17.66%
Properties: Crystals from methanol-methylene chloride, mp 252° (dec).
Melting point: mp 252° (dec)
Derivative Type: 21-Pivalate
CAS Registry Number: 34097-16-0
Manufacturers' Codes: CL-68; SH-863
Trademarks: Cloderm (Ortho); Purantix (Wander)
Molecular Formula: C27H36ClFO5
Molecular Weight: 495.02
Percent Composition: C 65.51%, H 7.33%, Cl 7.16%, F 3.84%, O 16.16%
Therap-Cat: Glucocorticoid.
Keywords: Glucocorticoid.
Clodinafop-Propargyl Clodronic Acid Clofarabine Clofenamide Clofencet

Clocortolone pivalate
Systematic (IUPAC) name
[2-(9-chloro-6-fluoro-11-hydroxy- 10,13,16-trimethyl- 3-oxo-7,8,11,12,14,15,16,17- octahydro- 6H-cyclopenta[a]phenanthren-17-yl)- 2-oxo-ethyl] 2,2-dimethylpropanoate
Clinical data
Trade names Cloderm
AHFS/ Consumer Drug Information
Pregnancy cat. C (US)
Legal status -only (US)
Routes Topical
CAS number 34097-16-0 YesY
ATC code D07AB21
PubChem CID 5282493
DrugBank DB00838
ChemSpider 4445634 YesY
KEGG D02287 YesY
ChEBI CHEBI:59583 YesY
Chemical data
Formula C27H36ClFO5 
Mol. mass 495.023 g/mol
 N (what is this?)  (verify)

Clocortolone (trade name Cloderm) is a topical steroid.[1] It is used in the form of an ester, clocortolone pivalate, and applied as a cream.[2]

This medication is used to treat a variety of skin conditions (e.g., eczema, dermatitis, allergies, rash). Clocortolone reduces the swelling, itching, and redness that can occur in these types of conditions. This medication is a medium-strength corticosteroid.

How to use Cloderm Top:

Use this medication on the skin only. However, do not use it on the face, groin, or underarms unless directed to do so by your doctor.

Wash and dry your hands before using. Clean and dry the affected area. Apply a thin film of medication to the affected area and gently rub in, usually 3 times daily or as directed by your doctor. Do not bandage, cover, or wrap the area unless directed to do so by your doctor. If used in the diaper area on an infant, do not use tight-fitting diapers or plastic pants.

After applying the medication, wash your hands unless you are using this medication to treat the hands. When applying this medication near the eyes, avoid getting it in the eyes because this may worsen or cause glaucoma. Also, avoid getting this medication in the nose or mouth. If you get the medication in these areas, rinse with plenty of water.

Use this medication only for the condition for which it was prescribed. Do not use it for longer than prescribed.

Inform your doctor if your condition persists or worsens after 2 weeks.

Cloderm Top Side Effects:

Stinging, burning, itching, irritation, dryness, or redness at the application site may occur when this medication is first applied to the skin. These effects should disappear in a few days as your body adjusts to the medication. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: stretch marks, skin thinning/discoloration, acne, extreme/unwanted hair growth, "hair bumps" (folliculitis).

Skin infections can become worse when this medication is used. Notify your doctor promptly if redness, swelling, or irritation does not improve.

Rarely, it is possible this medication will be absorbed from the skin into the bloodstream. This can lead to side effects of too much corticosteroid. These side effects are more likely in children, and in people who use this medication for a long time or over large areas of the skin. Tell your doctor right away if any of the following side effects occur: unusual/extreme tiredness, weight loss, headache, swelling ankles/feet, increased thirst/urination, vision problems.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.