Clofoctol

Title: Clofoctol
CAS Registry Number: 37693-01-9
CAS Name: 2-[(2,4-Dichlorophenyl)methyl]-4-(1,1,3,3-tetramethylbutyl)phenol
Additional Names: a-(2,4-dichlorophenyl)-4-(1,1,3,3-tetramethylbutyl)-o-cresol
Trademarks: Gramplus (Chiesi); Octofene (HMR)
Molecular Formula: C21H26Cl2O
Molecular Weight: 365.34
Percent Composition: C 69.04%, H 7.17%, Cl 19.41%, O 4.38%
Literature References: Prepn: J. Debat, US 3830852 (1974 to Inst. Recherches Chim. Biol. Appl.). Activity against gram positive and gram negative bacteria: A. Buogo, Drugs Exp. Clin. Res. 10, 321 (1984). Pharmacokinetics in rats: M. Del Tacca et al. in Recent Advances in Chemotherapy, Antimicrobial Section 3, J. Ishigami, Ed. (University of Tokyo Press, 1985) pp 1927-28; in man: eidem, J. Antimicrob. Chemother. 19, 679 (1987). Mechanism of action: J. Combe et al., J. Pharmacol. 11, 411 (1980); F. Yablonsky, G. Simonet, ibid. 13, 515 (1982). Clinical trials in respiratory infections: J. Vialatte, Diagnostics 207, 65 (1978); in infectious bronchopulmonary diseases: R. Danesi, M. Del Tacca, Int. J. Clin. Pharmacol. Res. 5, 175 (1985); in ear, nose and throat infections: P. L. Ghilardi, A. Casani, Drugs Exp. Clin. Res. 11, 815 (1985).
Properties: Crystals from petr ether, mp 78°. LD50 orally in male rats: >4 g/kg (Debat).
Melting point: mp 78°
Toxicity data: LD50 orally in male rats: >4 g/kg (Debat)
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Synthetic).
Cloforex Clomacran Clomazone Clomestrone Clometacin

Clofoctol
Clofoctol.svg
Systematic (IUPAC) name
2-[(2,4-dichlorophenyl)methyl]-
4-(2,4,4-trimethylpentan-2-yl)phenol
Clinical data
AHFS/Drugs.com International Drug Names
Legal status  ?
Routes Rectal (suppository)[1]
Pharmacokinetic data
Bioavailability 98%[1]
Metabolism Hepatic glucuronidation[1]
Excretion Biliary[1]
Identifiers
CAS number 37693-01-9 YesY
ATC code J01XX03
PubChem CID 2799
ChemSpider 2697 YesY
UNII 704083NI0R YesY
KEGG D07244 YesY
Chemical data
Formula C21H26Cl2O 
Mol. mass 365.336 g/mol
 YesY (what is this?)  (verify)

Clofoctol is a bacteriostatic antibiotic. It is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria.[1] It is marketed in France under the trade name Octoplus and in Italy as Gramplus.

It is only functional against Gram-positive bacteria.[2]

It penetrates into human lung tissue.[3]