Cloprednol

Title: Cloprednol
CAS Registry Number: 5251-34-3
CAS Name: (11b)-6-Chloro-11,17,21-trihydroxypregna-1,4,6-triene-3,20-dione
Additional Names: 6-chloro-D1,4,6-pregnatriene-11b,17a,21-triol-3,20-dione
Manufacturers' Codes: RS-4691
Trademarks: Cloradryn (Recordati); Novacort (Syntex); Syntestan (Syntex)
Molecular Formula: C21H25ClO5
Molecular Weight: 392.87
Percent Composition: C 64.20%, H 6.41%, Cl 9.02%, O 20.36%
Literature References: Prepn: H. J. Ringold, G. Rosenkranz, FR 1271981 C.A. 58, 1148a (1963); eidem, US 3232965 (1962, 1966 both to Syntex). Metabolic effects: E. Ortega et al., J. Clin. Pharmacol. 16, 122 (1976). Effects on hypothalamic-pituitary-adrenal axis function: eidem, J. Int. Med. Res. 4, 326 (1976). Bioavailability in humans: E. Mroszczak et al., J. Pharm. Sci. 67, 920 (1978). HPLC determn in plasma: C. Lee et al., ibid. 70, 669 (1981).
Properties: Crystals from acetone/hexane.
Therap-Cat: Glucocorticoid.
Keywords: Glucocorticoid.
Cloprostenol Clopyralid Cloquintocet-Mexyl Cloranolol Clorazepic Acid

Cloprednol
Cloprednol.png
Systematic (IUPAC) name
(9S,10R,11S,13S,14S,17R)-6-chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-9,11,12,14,15,16-hexahydro-8H-cyclopenta[a]phenanthren-3-one
Clinical data
AHFS/Drugs.com International Drug Names
Legal status  ?
Identifiers
CAS number 5251-34-3
ATC code H02AB14
PubChem CID 10023463
ChemSpider 4447592
UNII SYP56O3GJG YesY
KEGG D03561
Chemical data
Formula C21H25ClO5 
Mol. mass 392.873

Cloprednol is a synthetic glucocorticoid.[1] It has been investigated for use in asthma.[2]