Cloricromen

Title: Cloricromen
CAS Registry Number: 68206-94-0
CAS Name: [[8-Chloro-3-[2-(diethylamino)ethyl]-4-methyl-2-oxo-2H-1-benzopyran-7-yl]oxy]acetic acid ethyl ester
Additional Names: ethyl [[8-chloro-3-[2-(diethylamino)ethyl]-4-methyl-2-oxo-2H-1-benzopyran-7-yl]oxy]acetate; 8-monochloro-3-(b-diethylaminoethyl)-4-methyl-7-ethoxycarbonylmethoxycoumarin; 8-chlorocarbochromen; AD6
Molecular Formula: C20H26ClNO5
Molecular Weight: 395.88
Percent Composition: C 60.68%, H 6.62%, Cl 8.96%, N 3.54%, O 20.21%
Literature References: Derivative of coumarin, q.v. Prepn: F. della Valle, BE 871315; idem, US 4452811 (1979, 1984 both to Fidia). In vivo studies of activity as coronary vasodilator: F. Aporti et al., Pharmacol. Res. Commun. 10, 469 (1978); as inhibitor of platelet aggregation: M. Prosdocimi et al., Thromb. Res. 39, 399 (1985). Pharmacology in human platelets: R. A. Travagli et al., ibid. 54, 327 (1989). Mechanism of action: S. Porcellati et al., Agents Actions 29, 364 (1990).
Properties: Crystals from ethyl acetate, mp 147-148°.
Melting point: mp 147-148°
Derivative Type: Hydrochloride
CAS Registry Number: 74697-28-2
Trademarks: Cromocap (Fidia); Proendotel (Fidia)
Molecular Formula: C20H26ClNO5.HCl
Molecular Weight: 432.34
Percent Composition: C 55.56%, H 6.29%, Cl 16.40%, N 3.24%, O 18.50%
Properties: mp 219-220°.
Melting point: mp 219-220°
Therap-Cat: Antithrombotic; vasodilator (coronary).
Keywords: Antithrombotic; Vasodilator (Coronary).
Clorindione Clorophene Clorprenaline Clorsulon Clortermine

Cloricromen
Cloricromen.svg
Systematic (IUPAC) name
Ethyl 2-(8-chloro-3-(2-(diethylamino)ethyl)-4-methyl-2-oxo-2H-chromen-7-yloxy)acetate
Clinical data
Legal status  ?
Identifiers
CAS number 68206-94-0
ATC code B01AC02
PubChem CID 68876
ChemSpider 62108 YesY
UNII B9454PE93C YesY
KEGG D07139 YesY
ChEMBL CHEMBL255066 YesY
Chemical data
Formula C20H26ClNO5 
Mol. mass 395.877 g/mol
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Cloricromen is a platelet aggregation inhibitor.