Clortermine

Title: Clortermine
CAS Registry Number: 10389-73-8
CAS Name: 2-Chloro-a,a-dimethylbenzeneethanamine
Additional Names: o-chloro-a,a-dimethylphenethylamine; 1-(o-chlorophenyl)-2-methyl-2-propylamine; 1-(o-chlorophenyl)-2-methyl-2-aminopropane
Molecular Formula: C10H14ClN
Molecular Weight: 183.68
Percent Composition: C 65.39%, H 7.68%, Cl 19.30%, N 7.63%
Literature References: Prepn and use as anorexic agent: BE 665244; GB 1066616; Finocchio, Huebner, US 3415937 (1965, 1967, 1968, all to Ciba). Toxicity data: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).
Properties: bp16 116-118°.
Boiling point: bp16 116-118°
Derivative Type: Hydrochloride
CAS Registry Number: 10389-72-7
Manufacturers' Codes: Su-10568
Trademarks: Voranil (USV)
Molecular Formula: C10H14ClN.HCl
Molecular Weight: 220.14
Percent Composition: C 54.56%, H 6.87%, Cl 32.21%, N 6.36%
Properties: Crystals from ethanol, mp 245-246°. LD50 orally in rats: 332 ±23 mg/kg (Goldenthal).
Melting point: mp 245-246°
Toxicity data: LD50 orally in rats: 332 ±23 mg/kg (Goldenthal)
NOTE: This is a controlled substance (stimulant): 21 CFR, 1308.13.
Therap-Cat: Anorexic.
Keywords: Anorexic; CNS Stimulant.
Closantel Clospirazine Clostebol Clothiapine Clotiazepam

Clortermine
Clortermine.svg
Systematic (IUPAC) name
1-(2-chlorophenyl)-2-methylpropan-2-amine
Clinical data
Pregnancy cat.  ?
Legal status Prescription only
Routes Oral
Identifiers
CAS number 10389-73-8 N
ATC code None
PubChem CID 25223
DrugBank DB01527
ChemSpider 23558 YesY
UNII 4FA88HM3IX YesY
KEGG D03566 YesY
ChEMBL CHEMBL1697833 N
Synonyms 2-chloro-α,α-dimethylphenethylamine;
2-chloro-α-methylamphetamine;
2-chlorophentermine
Chemical data
Formula C10H14ClN 
Mol. mass 183.68 g/mol
 N (what is this?)  (verify)

Clortermine (Voranil) was developed by Ciba in the 1960s[1] and is an anorectic drug of the amphetamine class.[2] It is the 2-chloro analogue of the better known appetite suppressant phentermine, and is the 2-chloro positional isomer of chlorphentermine. Clortermine produces very low rates of self-administration in animals similarly to chlorphentermine,[3] and as a result it likely does not act on dopamine. Instead, it may act as a serotonin and/or norepinephrine releasing agent.[citation needed]