Clothiapine

Title: Clothiapine
CAS Registry Number: 2058-52-8
CAS Name: 2-Chloro-11-(4-methyl-1-piperazinyl)dibenzo[b,f][1,4]thiazepine
Trademarks: Entumine (Wander); Etumine (Wander)
Molecular Formula: C18H18ClN3S
Molecular Weight: 343.87
Percent Composition: C 62.87%, H 5.28%, Cl 10.31%, N 12.22%, S 9.32%
Literature References: Prepn: FR CAM 51 (1964 to Dr. A. Wander), C.A. 61, 8328h (1964).
Properties: Crystals from ether + petr ether, mp 118-120°.
Melting point: mp 118-120°
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Other Tricyclics.
Clotiazepam Clove Cloxacillin Cloxazolam Cloxotestosterone

Clotiapine
Clotiapine2DACS.svg
Systematic (IUPAC) name
8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,5]benzothiazepine
Clinical data
Trade names Etumina, Etumine, Entumin, Etomine, Entumine
AHFS/Drugs.com International Drug Names
Legal status Prescription only
Routes Oral, Intravenous and Intramuscular
Identifiers
CAS number 2058-52-8 N
ATC code N05AH06
PubChem CID 16351
ChemSpider 15510 YesY
UNII Z05HCY0X1T YesY
KEGG D01597 YesY
ChEMBL CHEMBL304902 YesY
Chemical data
Formula C18H18ClN3S 
Mol. mass 343.87 g/mol
 N (what is this?)  (verify)

Clotiapine (Entumine) is an atypical antipsychotic[1] of the dibenzothiazepine chemical class.[2] It was first introduced in a few European countries (namely, Belgium, Italy, Spain and Switzerland), Argentina, Taiwan and Israel in 1970.[3]

Some sources regard clotiapine as a typical antipsychotic rather than atypical due to its high incidence of extrapyramidal side effects compared to the atypicals like clozapine and quetiapine, to which it is structurally related.[4] Despite its profile of a relatively high incidence of extrapyramidal side effects it has demonstrated efficacy in treatment-resistant schizophrenic patients according to a number of psychiatrists with clinical experience with it, some weak clinical evidence supports this view too.[4][5][3]