Codamine

Title: Codamine
CAS Registry Number: 21040-59-5
CAS Name: (1S)-1-[(3,4-Dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinol
Additional Names: 1,2,3,4-tetrahydro-6-methoxy-2-methyl-1-veratryl-7-isoquinolinol
Molecular Formula: C20H25NO4
Molecular Weight: 343.42
Percent Composition: C 69.95%, H 7.34%, N 4.08%, O 18.64%
Literature References: Minor opium alkaloid. Constitutes about 0.003% of Turkish opium. Isoln: Hesse, Ann. 282, 213 (1894). Structure: Späth, Epstein, Ber. 59B, 2791 (1926). Synthesis: Schöpf, Thierfelder, Ann. 537, 143 (1939); Billek, Monatsh. Chem. 87, 106 (1956).
Derivative Type: dl-Form
Properties: Large, six-sided prisms from ether, mp 127°. Very sol in alcohol, chloroform. Somewhat sol in boiling water. In soln codamine reacts strongly basic. The salts are bitter in taste, whereas the base is said to be tasteless.
Melting point: mp 127°
Codeine Codeine Methyl Bromide Codeine N-Oxide Codeine Phosphate Coenzyme A