Colesevelam Hydrochloride

Title: Colesevelam Hydrochloride
CAS Registry Number: 182815-44-7
CAS Name: N,N,N-Trimethyl-6-(2-propenylamino)-1-hexanaminium chloride polymer with (chloromethyl)oxirane, 2-propen-1-amine and N-2-propenyl-1-decanamine, hydrochloride
Manufacturers' Codes: GT-31-104
Trademarks: CholestaGel (GelTex); Welchol (Sankyo)
Literature References: Bile acid sequestrant composed of a polyallylamine cross-linked with epichlorohydrin and alkylated with 1-bromodecane and 6-bromohexyltrimethylammonium bromide. Prepn: H. W. Mandeville, III, S. R. Holmes-Farley, WO 9534585; eidem, US 5693675 (1995, 1997 both to GelTex); and bile acid binding: W. H. Mandeville et al., Mater. Res. Soc. Symp. Proc. 550, 3 (1999). Absorption, distribution and excretion: D. P. Rosenbaum et al., J. Pharm. Sci. 86, 591 (1997). Clinical trial in hypercholesterolemia: W. Insull, Jr. et al., Mayo Clin. Proc. 76, 971 (2001). Review of pharmacology and clinical experience: M. A. Aldridge, M. K. Ito, Ann. Pharmacother. 35, 898-907 (2001).
Therap-Cat: Antilipemic.
Keywords: Antilipemic; Bile Acid Sequesterants.
Colestilan Colestipol Colforsin Colfosceril Palmitate Colicins

Colesevelam structure.svg
Clinical data
Trade names Welchol, Cholestagel
AHFS/ monograph
MedlinePlus a699050
Pregnancy cat. B
Legal status Prescription only
Routes Oral
Pharmacokinetic data
Bioavailability N/A
Metabolism Colesevelam is not absorbed and not metabolised.
Half-life N/A (non-systemic drug)
Excretion By intestines only, colesevelam is non-systemic.
CAS number 182815-44-7 YesY
ATC code C10AC04
PubChem CID 160051
DrugBank DB00930
KEGG D03582 YesY
Chemical data
Formula  ?
 N (what is this?)  (verify)

Colesevelam is a bile acid sequestrant administered orally. It is developed by Genzyme and marketed in the US by Daiichi Sankyo under the brand name Welchol and elsewhere by Genzyme as Cholestagel. In Canada it is marketed by Valeant as Lodalis.