Colicins

Title: Colicins
Additional Names: Colicine
Literature References: Antibiotic substances, or complexes of antibiotic substances, which are highly specific, are produced by certain strains of intestinal bacteria, and act upon other related strains: Fredericq, Annu. Rev. Microbiol. 11, 7 (1957). Colicins produced by various strains may differ in many characteristics, the most conspicuous of which are activity spectra and the specificity of resistant mutants. They give the general reactions of proteins, are antigenic, and their activity is destroyed by proteolytic enzymes: Fredericq, J. Theor. Biol. 4, 159 (1963). Production of colicin A: Barry et al., Nature 198, 211 (1963); of colicin V: Hutton, Goebel, Proc. Natl. Acad. Sci. USA 47, 1498 (1961); of colicins E4, N, P,V2, V3, V4 and V5: Hamon, Péron, Ann. Inst. Pasteur 107, 44 (1964). Mechanism of action of colicins: Nomura, Proc. Natl. Acad. Sci. USA 52, 1514 (1964). Reviews: idem in Antibiotics vol. 1, D. Gottlieb, P. D. Shaw, Eds. (Springer-Verlag, New York, 1967) pp 696-704; Wendt, ibid. vol. 3, J. W. Corcoran, F. E. Hahn, Eds. (1975) pp 588-605.
Colistin Collagenase Collinomycin Collinsonia Colloidal Bismuth Subcitrate

Colicin
PDB 2ivz EBI.jpg
structure of tolb in complex with a peptide of the colicin e9 t-domain
Identifiers
Symbol Colicin
Pfam PF03515
Pfam clan CL0446
InterPro IPR003058
SCOP 1jch
SUPERFAMILY 1jch

A colicin is a type of bacteriocin produced by and toxic to some strains of Escherichia coli.[1] Colicins are released into the environment to reduce competition from other bacterial strains. Colicins bind to outer membrane receptors, using them to translocate to the cytoplasm or cytoplasmic membrane, where they exert their cytotoxic effect, including depolarisation of the cytoplasmic membrane, DNase activity, RNase activity, or inhibition of murein synthesis.