Coumachlor

Title: Coumachlor
CAS Registry Number: 81-82-3
CAS Name: 3-[1-(4-Chlorophenyl)-3-oxobutyl]-4-hydroxy-2H-1-benzopyran-2-one
Additional Names: 3-(a-acetonyl-p-chlorobenzyl)-4-hydroxycoumarin; 3-(a-p-chlorophenyl-b-acetylethyl)-4-hydroxycoumarin
Manufacturers' Codes: G-21133
Molecular Formula: C19H15ClO4
Molecular Weight: 342.77
Percent Composition: C 66.58%, H 4.41%, Cl 10.34%, O 18.67%
Literature References: Structural analog of warfarin. Prepn: F. Litvan, W. Stoll, US 2648682 (1953 to J. R. Geigy). Anticoagulant activity: M. Reiff, R. Weismann, Acta Trop. 8, 97 (1951), C.A. 50, 10976d (1956). Review of comparative toxicology: H. Wanntorp, Acta Pharmacol. Toxicol. 16, Suppl. 2, 123 pp (1959).
Properties: Crystals, mp 169-171°. Sol in alc, acetone, chloroform. Slightly sol in benzene, ether. Practically insol in water. MLD in dog, swine (mg/kg): <5, <5 orally (Wanntorp).
Melting point: mp 169-171°
Toxicity data: MLD in dog, swine (mg/kg): <5, <5 orally (Wanntorp)
CAUTION: Similar to warfarin, with delayed actions on prothrombin level and blood clotting, resulting in death by hemorrhage. See Clinical Toxicology of Commercial Products, R.E. Gosselin et al., Eds. (Williams & Wilkins, Baltimore, 5th ed., 1984) Section II, pp 348.
Use: Rodenticide.
Coumafuryl Coumalic Acid Coumaphos Coumaran Coumarilic Acid

Coumachlor
Coumachlor.svg
Identifiers
CAS number 81-82-3
PubChem 6692
Jmol-3D images Image 1
Properties
Molecular formula C19H15ClO4
Molar mass 342.77 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Coumachlor is a 1st genereation anticoagulant rodenticide which blocks formation of prothrombin and inhibits blood coagulation causing death by internal haemorrhage.[1][2] Although the compound is non-hazardous but toxicological properties have not been researched yet.[3] The chemical can be absorbed through the skin.[4] The symptoms of human contact can be nosebleeds, bleeding gums, bloody urine, extensive bruising in the absence of injury, fatigue, shortness of breath (dyspnea) on exertion. The human consumption or inhalation of compound can also cause fluid in lungs (pulmonary edema).