Cyclonium Iodide

Title: Cyclonium Iodide
CAS Registry Number: 6577-41-9
CAS Name: 1-[(2-Cyclohexyl-2-phenyl-1,3-dioxolan-4-yl)methyl]-1-methylpiperidinium iodide
Additional Names: N-methyl-N-[(2-cyclohexyl-2-phenyl-1,3-dioxolan-4-yl)-methyl]piperidinium iodide; 1-(2-phenyl-2-cyclohexyl-1,3-dioxolan-4-yl)methyl-1-methylpiperidinium iodide; ciclonium iodide; oxapium iodide
Manufacturers' Codes: SH-100
Trademarks: Esperan (Toyama)
Molecular Formula: C22H34INO2
Molecular Weight: 471.42
Percent Composition: C 56.05%, H 7.27%, I 26.92%, N 2.97%, O 6.79%
Literature References: Prepn: M. Kimura et al., JP 66 6585 (1966 to Toyama), C.A. 65, 7191 (1966); and separation of isomers: I. Saikawa, JP 70 16475 (1970 to Toyama), C.A. 73, 45355t. Stability studies: Shiuchi, Miyazaki, Bunseki Kagaku 18, 455 (1969), C.A. 71, 74097z (1969). Incompatibility studies: Kunita et al., Yakuzaigaku 28, 84 (1968), C.A. 69, 99335x (1968). Anticholinergic activity and acute toxicity: J. Faff et al., Pol. J. Pharmacol. Pharm. 30, 493 (1978). Review: Jpn. Med. Gaz. 8(9), 11 (1971).
Derivative Type: a-Form
Properties: White crystals from monochlorobenzene or isopropyl alcohol, mp 195-197°. Insol in trichloroethylene.
Melting point: mp 195-197°
Derivative Type: b-Form
Properties: White crystals from monochlorobenzene, mp 150-152°. Sol in hot trichloroethylene. Both sol in methanol, ethanol, chloroform and tetrachlorethane. Hardly sol in benzene, toluene, xylene and water. LD50 i.p. in mice: 106 mg/kg (Faff).
Melting point: mp 150-152°
Toxicity data: LD50 i.p. in mice: 106 mg/kg (Faff)
Therap-Cat: Antispasmodic.
Keywords: Antispasmodic.
Cyclooctyne Cyclopentadiene Cyclopentamine Cyclopentane Cyclopentanol