Cycrimine Hydrochloride

Title: Cycrimine Hydrochloride
CAS Registry Number: 126-02-3
CAS Name: a-Cyclopentyl-a-phenyl-1-piperidinepropanol hydrochloride
Additional Names: 1-phenyl-1-cyclopentyl-3-piperidino-1-propanol hydrochloride
Manufacturers' Codes: compd 8958
Trademarks: Pagitane hydrochloride (Lilly)
Molecular Formula: C19H30ClNO
Molecular Weight: 323.90
Percent Composition: C 70.45%, H 9.34%, Cl 10.95%, N 4.32%, O 4.94%
Literature References: Anticholinergic. Prepd by the addition of a Grignard reagent to the corresponding b-aminoketone: Denton et al., J. Am. Chem. Soc. 72, 3795 (1950).
Properties: Crystals, dec 241-244°. Very bitter taste. Soly (g/100 ml) at 25° in water: 0.6; in ethanol: 2.0; in chloroform: 3.0. pH of a 0.5% aq soln: 4.9-5.4.
Therap-Cat: Antiparkinsonian.
Keywords: Antiparkinsonian; Antimuscarinic.
Status: This monograph has been retired and is no longer subject to revision or update.
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