D-Mannitol Hexanitrate

Title: D-Mannitol Hexanitrate
CAS Registry Number: 15825-70-4
Additional Names: Mannitol nitrate; nitromannite; nitromannitol
Trademarks: Medemanol; Dilangil; Moloid (Smedica); Mannitrin; Manexin
Molecular Formula: C6H8N6O18
Molecular Weight: 452.16
Percent Composition: C 15.94%, H 1.78%, N 18.59%, O 63.69%
Literature References: Made by nitration of mannitol: Fleury et al., Mem. Poudres 31, 107 (1949).
Properties: Long needles in regular clusters from alc. mp 106-108°. Soluble in alc, in ether; insol in water. Explodes on percussion. Its stability at ordinary temps is such that it may be used commercially, but it is distinctly less stable than nitroglycerol at 75°. Its employ for pharmaceutical prepns is only in admixture with carbohydrate substances in dilutions corresponding to 1 part of mannitol hexanitrate to 9 or more parts of carbohydrate. In such dilutions mannitol hexanitrate is considered nonexplosive.
Melting point: mp 106-108°
Therap-Cat: Vasodilator.
Keywords: Vasodilator (Coronary).
D-manno-Heptulose D-Mannose DMAP DMC DMMP