Dalteparin

Title: Dalteparin
Additional Names: Tedelparin
Literature References: Low molecular weight fragment of heparin, q.v., prepd by nitrous acid depolymerization of porcine mucosal heparin. Mean mol wt 4000-6000 daltons. Prepn: U. Lindahl et al., WO 8001383; eidem, US 4303651 (1980, 1981 both to Kabi AB). See also: eidem, Proc. Natl. Acad. Sci. USA 76, 3198 (1979). Comparison of bioactivity with standard heparin: E. Holmer et al., Thromb. Res. 18, 861 (1980). Clinical pharmacokinetics: G. Bratt et al., ibid. 42, 613 (1986). Symposia on pharmacology and clinical efficacy: Haemostasis 16, Suppl. 2, 1-71 (1986); Semin. Thromb. Hemostasis 16, Suppl., 1-76 (1990). Clinical trial in unstable angina: W. Klein et al., Circulation 96, 61 (1997); in unstable coronary artery disease: FRISC II Investigators, Lancet 354, 701 (1999). Review: C. J. Dunn, E. M. Sorkin, Drugs 52, 276-305 (1996).
Derivative Type: Sodium salt
Manufacturers' Codes: Kabi 2165; FR-860
Trademarks: Boxol (Pharmacia & Upjohn); Fragmin (Pharmacia & Upjohn)
Therap-Cat: Antithrombotic.
Keywords: Antithrombotic.
Daltroban D-Altrose Damar Damascenine D-Amino Acid Oxidase

Dalteparin sodium
Clinical data
AHFS/Drugs.com International Drug Names
Legal status  ?
Identifiers
CAS number 9041-08-1
ATC code B01AB04
DrugBank DB06779
KEGG D03353
Chemical data
Formula  ?

Dalteparin is a low molecular weight heparin. It is marketed as Fragmin by Pfizer Inc. Like other low molecular weight heparins, dalteparin is used for prophylaxis or treatment of deep vein thrombosis and pulmonary embolism.

The CLOT study, published in 2003, showed that in patients with malignancy and acute venous thromboembolism, dalteparin was more effective than warfarin in reducing the risk of recurrent embolic events.[1] Dalteparin is not superior to unfractionated heparin in preventing blood clots.[2]

Heparins are cleared by the kidneys, but studies have shown that dalteparin does not accumulate even if kidney function is reduced.[3]