Title: Danaparoid
Additional Names: Mucoglucoronan
Literature References: Low molecular weight heparinoid derived from hog intestinal mucosa. Mixture of glycosaminoglycans with a mean mol wt of 6000 Da (range 4000-10000 Da). Consists of heparan sulfate (~83%), dermatan sulfate (~12%) and chondroitin sulfate (~5%). Prepn: A. L. M. Saunders et al., EP 66908; eidem, US 4438108 (1982, 1984 both to Akzo). Pharmacology: D. G. Meuleman et al., Thromb. Res. 27, 353 (1982). Determn in plasma: H. ten Cate et al., Clin. Chem. 30, 860 (1984). Series of articles on pharmacology and clinical efficacy: Haemostasis 22, 55-112 (1992). Clinical trial in deep venous thromboembolism: H. W. de Valk et al., Ann. Intern. Med. 123, 1 (1995).
Derivative Type: Sodium salt
Manufacturers' Codes: Org-10172
Trademarks: Orgaran (Organon)
Therap-Cat: Antithrombotic.
Keywords: Antithrombotic.
Danazol Danofloxacin Dansyl Chloride Danthron Dantrolene

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Danaparoid sodium (Orgaran) is an anticoagulant[1] that works by inhibiting activated factor X (factor Xa).

Danaparoid is a heparinoid but considered to be a low molecular weight heparin by some sources. However it is chemically distinct from heparin, has different protein binding properties and thus has little cross-reactivity in heparin-intolerant patients.

It consists of a mixture of heparan sulfate, dermatan sulfate, and chondroitin sulfate.[2]