Dapiprazole

Title: Dapiprazole
CAS Registry Number: 72822-12-9
CAS Name: 5,6,7,8-Tetrahydro-3-[2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-1,2,4-triazolo[4,3-a]pyridine
Additional Names: 5,6,7,8-tetrahydro-3-[2-(4-o-tolyl-1-piperazinyl)ethyl]-s-triazolo[4,3-a]pyridine
Molecular Formula: C19H27N5
Molecular Weight: 325.45
Percent Composition: C 70.12%, H 8.36%, N 21.52%
Literature References: a-Adrenergic blocker. Prepn: B. Silvestrini, L. Baiocchi, DE 2915318; eidem, US 4252721 (1979, 1981 both to Angelini Francesco). Series of articles on general pharmacology: Arzneim.-Forsch. 32, 674-681 (1982); and toxicity: B. Silvestrini et al., ibid. 668. Ocular pharmacokinetics in rabbits: P. Valeri et al., Pharmacol. Res. Commun. 18, 1093 (1986). Topical effects in human eye: A. Reibaldi et al., Acta Ther. 10, 381 (1984); C. Malpassi et al., ibid. 12, 55 (1986). Clinical trial in reversal of mydriasis: R. W. Allinson et al., Ann. Ophthalmol. 22, 131 (1990).
Properties: mp 158-160°.
Melting point: mp 158-160°
Derivative Type: Monohydrochloride
CAS Registry Number: 72822-13-0
Manufacturers' Codes: AF-2139
Trademarks: Glamidolo (Angelini); Reversil (Angelini); Rev-Eyes (Angelini)
Molecular Formula: C19H27N5.HCl
Molecular Weight: 361.91
Percent Composition: C 63.06%, H 7.80%, N 19.35%, Cl 9.80%
Properties: Crystals from absolute ethanol, mp 206-207°. LD50 in mice (mg/kg): 260 i.p. (Silvestrini).
Melting point: mp 206-207°
Toxicity data: LD50 in mice (mg/kg): 260 i.p. (Silvestrini)
Therap-Cat: Antiglaucoma; miotic.
Keywords: a-Adrenergic Blocker; Antiglaucoma.
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Dapiprazole
Dapiprazole.svg
Systematic (IUPAC) name
3-{2-[4-(2-methylphenyl)piperazin-1-yl]ethyl}-5,6,7,8-
tetrahydro-[1,2,4]triazolo[4,5-a]pyridine
Clinical data
AHFS/Drugs.com Consumer Drug Information
MedlinePlus a601043
Pregnancy cat. B
Legal status Prescription only
Routes Topical (eye drops)
Pharmacokinetic data
Bioavailability Negligible when administered topically
Identifiers
CAS number 72822-12-9 YesY
ATC code S01EX02
PubChem CID 3033538
DrugBank DB00298
ChemSpider 2298190 YesY
UNII 5RNZ8GJO7K YesY
KEGG D07775 YesY
ChEBI CHEBI:51066 YesY
ChEMBL CHEMBL1201216 N
Chemical data
Formula C19H27N5 
Mol. mass 325.451 g/mol
 N (what is this?)  (verify)

Dapiprazole (Rev-Eyes) is an alpha blocker. It is used to reverse mydriasis after eye examination.[1]