Title: Darbepoetin Alfa
CAS Registry Number: 209810-58-2
CAS Name: [30-Asparagine,32-threonine,87-valine,88-asparagine,90-threonine]erythropoietin (human)
Additional Names: novel erythropoiesis stimulating protein; NESP
Trademarks: Aranesp (Amgen)
Literature References: Hyperglycosylated analog of human erythropoietin, q.v., produced by recombinant DNA technology. mol wt ~38 kDa. Engineered to contain 2 extra carbohydrate addition sites, leading to increased circulating half-life. Prepn: S. G. Elliott, T. E. Byrne, WO 9505465 (1995 to Amgen). Review of development and pharmacology: I. C. Macdougall, Semin. Nephrol. 20, 375-381 (2000); of clinical experience in treatment of anemia of kidney disease: A. R. Nissenson, Am. J. Kidney Dis. 38, 1390-1397 (2001); of chemotherapy induced anemia: J. Vansteenkiste, I. Wauters, Expert Opin. Pharmacother. 6, 429-440 (2005). Series of articles on clinical experience in cancer-related anemia: Br. J. Cancer 84, Suppl. 1, 1-38 (2001).