Defibrotide

Title: Defibrotide
CAS Registry Number: 83712-60-1
Additional Names: Fraction P; defibrinotide
Trademarks: Dasovas (Erba); Noravid (HMR); Prociclide (Crinos)
Literature References: Sodium salt of polydeoxyribonucleotide extract from mammalian lung which stimulates fibrinolysis. mol wt 45,000-50,000 daltons. Prepn: A. Butti et al., DE 2154278; eidem, US 3899481 (1972, 1975 both to Crinos). Antithrombotic activity: R. Niada et al., Thromb. Res. 23, 233 (1981). Pharmacokinetics and profibrinolytic activity in rabbits: R. Pescador et al., ibid. 30, 1 (1983). Clinical trial as antithrombotic: S. Coccheri et al., Int. J. Clin. Pharmacol. Res. 2, 227 (1982). Clinical evaluation in thrombotic microangiopathy: V. Bonomini et al., Nephron 40, 195 (1985). Symposium on pharmacology and clinical efficacy: O. N. Ulutin, Ed., Haemostasis 16, Suppl. 1, 1-68 (1986). Review of pharmacology and therapeutic use: K. J. Palmer, K. L. Goa, Drugs 45, 259-294 (1993).
Therap-Cat: Antithrombotic.
Keywords: Antithrombotic.
Deflazacort Defosfamide DEHP Dehydroacetic Acid Dehydroascorbic Acid

Defibrotide
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat. X
Legal status Rx only (where available)
Routes oral, i.m., i.v.
Pharmacokinetic data
Bioavailability 58 - 70% orally (i.v. and i.m. = 100%)
Half-life t1/2-alpha = minutes; t1/2-beta = a few hours
Identifiers
CAS number 83712-60-1 YesY
ATC code B01AX01
DrugBank DB04932
UNII 438HCF2X0M YesY
KEGG D07423 YesY
Chemical data
Formula  ?
 N (what is this?)  (verify)

Defibrotide is a deoxyribonucleic acid derivative (single-stranded) derived from cow lung or porcine mucosa. It is an anticoagulant with a multiple mode of action (see below).

It has been used with antithrombin III.[1]