Denopterin

Title: Denopterin
CAS Registry Number: 22006-84-4
CAS Name: N-[4-[[1-(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)ethyl]methylamino]benzoyl]-L-glutamic acid
Additional Names: 9,10-dimethylpteroylglutamic acid; N10,9-dimethylfolic acid
Trademarks: Dimetfol
Molecular Formula: C21H23N7O6
Molecular Weight: 469.45
Percent Composition: C 53.73%, H 4.94%, N 20.89%, O 20.45%
Literature References: Prepn: Hultquist et al., J. Am. Chem. Soc. 71, 619 (1949); Hultquist, Smith, GB 667098 (1952 to Am. Cyanamid).
Properties: Yellow-orange microcrystals. uv max (0.1N NaOH): 253, 305, 365 nm; (0.1N HCl): 315 nm.
Absorption maximum: uv max (0.1N NaOH): 253, 305, 365 nm; (0.1N HCl): 315 nm
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Antimetabolites; Folic Acid Analogs/Antagonists.
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