Title: Deracoxib
CAS Registry Number: 169590-41-4
CAS Name: 4-[3-(Difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-1H-pyrazol-1-yl]benzenesulfonamide
Manufacturers' Codes: SC-046; SC-59046
Trademarks: Deramaxx (Novartis)
Molecular Formula: C17H14F3N3O3S
Molecular Weight: 397.37
Percent Composition: C 51.38%, H 3.55%, F 14.34%, N 10.57%, O 12.08%, S 8.07%
Literature References: Selective cyclooxygenase-2 (COX-2) inhibitor. Prepn: J. J. Talley et al., WO 9515316; M. J. Graneto, US 5521207 (1995, 1996 both to Searle); T. D. Penning et al., J. Med. Chem. 40, 1347 (1997). Structure activity study: G. R. Desiraju et al., Molecules 5, 945 (2000). Effect in experimental synovitis in dogs: D. L. Millis et al, Vet. Ther. 3, 453 (2002); HPLC determn in plasma: S. K. Cox et al., J. Chromatogr. B 819, 181 (2005).
Properties: Light tan solid, mp 159-161°.
Melting point: mp 159-161°
Therap-Cat-Vet: Anti-inflammatory; analgesic.
Deramciclane Dermostatin Derris Root D-Erythrose D-Erythrose 4-Phosphate

Systematic (IUPAC) name
4-[3-(Difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-1H-pyrazole-1-yl] benzenesulfonamide
Clinical data
AHFS/ International Drug Names
Pregnancy cat. unknown
Legal status veterinary prescription only
Routes oral
Pharmacokinetic data
Protein binding high (more than 90%)
Metabolism hepatic biotransformation
Half-life 3 hours at 2–3 mg/kg
Excretion in feces
CAS number 169590-41-4 N
ATC code None
PubChem CID 3058754
ChemSpider 2319853 YesY
Chemical data
Formula C17H14F3N3O3S 
Mol. mass 397.38
 N (what is this?)  (verify)

Deracoxib (trade name Deramaxx, Novartis) is a non-steroidal anti-inflammatory drug of the coxib class, used in veterinary medicine to treat osteoarthritis in dogs. It is sold in tablets, which have added beefy flavor to increase palatability. Deramaxx received FDA approval in August 2002 for "the control of post operative pain and inflammation associated with orthopedic surgery in dogs."