Deslanoside

Title: Deslanoside
CAS Registry Number: 17598-65-1
CAS Name: (3b,5b,12b)-3-[(O-b-D-Glucopyranosyl-(1®4)-O-2,6-dideoxy-b-D-ribo-hexopyranosyl-(1®4)-O-2,6-dideoxy-b-D-ribo-hexopyranosyl-(1®4)-2,6-dideoxy-b-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide
Additional Names: deacetyllanatoside C; desacetyldigilanide C
Trademarks: Cedilanide (Novartis); Desace (Dexo); Desaci (Simes)
Molecular Formula: C47H74O19
Molecular Weight: 943.08
Percent Composition: C 59.86%, H 7.91%, O 32.23%
Literature References: Cardiac glycoside. Isoln from leaves of Digitalis lanata Ehrh., Scrophulariaceae: Stoll, Kreis, Helv. Chim. Acta 16, 1049, 1390 (1933). Prepn by alkaline degradation of lanatoside C: Kroszczynski et al., Acta Pol. Pharm. 21, 357 (1964), C.A. 62, 10292b (1965). Hemodynamic effects in heart failure: E. Ambrosioni et al., Int. J. Clin. Pharmacol. Biopharm. 17, 416 (1979). Clinical pharmacokinetics: A. Marzo et al., Farmaco Ed. Prat. 37, 28 (1982). Determn in blood and urine by HPLC/MS/MS: F. Guan et al., Anal. Chem. 71, 4034 (1999).
Properties: Crystals from methanol, dec 265-268°. [a]D20 +12° (c = 1.084 in 75% alc). One part dissolves in 5000 parts water, 200 parts methanol and 2500 parts ethanol; very slightly sol in chloroform. Practically insol in ether.
Optical Rotation: [a]D20 +12° (c = 1.084 in 75% alc)
Therap-Cat: Cardiotonic.
Keywords: Cardiotonic.
Desloratadine Deslorelin Desmopressin Desmosterol Desogestrel

Deslanoside
Deslanoside CASCC.png
Systematic (IUPAC) name
(3β,5β,12β)-3-[(O-β-D-glucopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide
Clinical data
AHFS/Drugs.com International Drug Names
Legal status  ?
Identifiers
CAS number 17598-65-1 YesY
ATC code C01AA07
PubChem CID 28620
DrugBank DB01078
ChemSpider 26618 YesY
UNII YGY317RK75 YesY
KEGG D01240 YesY
ChEBI CHEBI:31468 YesY
ChEMBL CHEMBL1614 YesY
Chemical data
Formula C47H74O19 
Mol. mass 943.08 g/mol
 YesY (what is this?)  (verify)

Deslanoside (trade name Cedilanide in Brazil[1]) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). It is found in the leaves of Digitalis lanata, the Woolly Foxglove.[2][3]