Desloratadine

Title: Desloratadine
CAS Registry Number: 100643-71-8
CAS Name: 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
Additional Names: descarboethoxyloratadine
Manufacturers' Codes: Sch-34117
Trademarks: Clarinex (Schering-Plough)
Molecular Formula: C19H19ClN2
Molecular Weight: 310.82
Percent Composition: C 73.42%, H 6.16%, Cl 11.41%, N 9.01%
Literature References: Nonsedating-type histamine H1-receptor antagonist; active metabolite of loratadine, q.v. Also inhibits generation and release of inflammatory mediators from basophils and mast cells. Prepn: D. P. Schumacher et al., EP 208855; F. J. Villani, J. K. Wong, US 4659716 (both 1987 to Schering). GLC determn in plasma: R. Johnson et al., J. Chromatogr. B 657, 125 (1994). Pharmacology: W. Kreutner et al., Arzneim.-Forsch. 50, 345 (2000). Series of articles on clinical efficacy in rhinitis, asthma and urticaria: Allergy 56, Suppl. 65, 1-32 (2001). Review of pharmacology, pharmacokinetics and clinical efficacy: R. S. Geha, E. O. Meltzer, J. Allergy Clin. Immunol. 107, 751-762 (2001); D. K. Agrawal, Expert Opin. Invest. Drugs 10, 547-560 (2001).
Properties: Crystals from hexane, mp 150-151°. Slightly sol in water; very sol in ethanol, propylene glycol.
Melting point: mp 150-151°
Therap-Cat: Antihistaminic.
Keywords: Antihistaminic; Tricyclics; Other Tricyclics.
Deslorelin Desmopressin Desmosterol Desogestrel Desomorphine

Desloratadine
Desloratadine.svg
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Systematic (IUPAC) name
8-chloro-6,11-dihydro-11-(4-piperdinylidene)- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine
Clinical data
Trade names Clarinex
AHFS/Drugs.com monograph
MedlinePlus a602002
Licence data EMA:Link, US FDA:link
Pregnancy cat. B1 (AU) C (US)
Legal status POM (UK) -only (US)
Routes oral
Pharmacokinetic data
Bioavailability Rapidly absorbed
Protein binding 85%
Metabolism Liver
Half-life 27 hours
Excretion 40% as conjugated metabolites into urine
Similar amount into the feces
Identifiers
CAS number 100643-71-8 YesY
ATC code R06AX27
PubChem CID 124087
DrugBank DB00967
ChemSpider 110575 YesY
UNII FVF865388R YesY
KEGG D03693 YesY
ChEBI CHEBI:291342 YesY
ChEMBL CHEMBL1172 YesY
Chemical data
Formula C19H19ClN2 
Mol. mass 310.82
 YesY (what is this?)  (verify)

Desloratadine is a drug used to treat allergies. It is marketed under several trade names such as NeoClarityn, Claramax, Clarinex, Larinex, Aerius, Dazit, Azomyr, Deselex and Delot. It is an active metabolite of loratadine, which is also on the market.