Title: Deslorelin
CAS Registry Number: 57773-65-6
CAS Name: 6-D-Tryptophan-9-(N-ethyl-L-prolinamide)-10-deglycinamideluteinizing hormone-releasing factor (pig)
Additional Names: [D-Trp6,des-Gly10]-LH-RH ethylamide
Trademarks: Somagard (Roberts)
Molecular Formula: C64H83N17O12
Molecular Weight: 1282.45
Percent Composition: C 59.94%, H 6.52%, N 18.57%, O 14.97%
Literature References: Synthetic nonapeptide agonist analog of LH-RH, q.v. Prepn: D. H. Coy et al., J. Med. Chem. 19, 423 (1976); W. Kornreich et al., Int. J. Pept. Protein Res. 25, 414 (1985). Pharmacology: K. Sundaram et al., Life Sci. 28, 83 (1981). Pharmacokinetics and metabolism: B. Candas et al., J. Clin. Endocrinol. Metab. 70, 1046 (1990). Clinical inhibition of spermatogenesis: R. Linde et al., N. Engl. J. Med. 305, 663 (1981). Clinical trial in combination with flutamide, q.v., for prostatic carcinoma: A. Dupont et al., Eur. J. Cancer Clin. Oncol. 24, 659 (1988). Clinical evaluation in precocious puberty: P. K. Manasco et al., J. Pediatr. 115, 105 (1989).
Properties: [a]D24 -61° (c = 0.37 in 0.1M acetic acid).
Optical Rotation: [a]D24 -61° (c = 0.37 in 0.1M acetic acid)
Therap-Cat: Treatment of precocious puberty.
Keywords: LH-RH Agonist.
Desmopressin Desmosterol Desogestrel Desomorphine Desonide

Systematic (IUPAC) name
Clinical data
Trade names Ovuplant
AHFS/ International Drug Names
Pregnancy cat. X (USA)
Legal status  ?
Routes implant / Inhalation
Pharmacokinetic data
Excretion renal
CAS number 57773-65-6 N
ATCvet code QH01CA93
PubChem CID 25074999
Chemical data
Formula C64H83N17O12 
Mol. mass 1282.45 g/mol
 N (what is this?)  (verify)

Deslorelin acetate is an injectable gonadotropin releasing hormone super-agonist (GnRH agonist) also known as an LHRH agonist. It stops the production of sex hormones (testosterone and oestrogen).

Deslorelin Acetate is marketed by Peptech with the brand name Ovuplant.[1] It is currently approved for use in veterinary medicine and is used to induce ovulation in mares as part of the artificial insemination process. It is also used to stabilize high-risk pregnancies, mainly of livestock. Unlike other GnRH agonists, which are mainly used to inhibit luteinizing hormone and follicle-stimulating hormone by their ultimate downregulation of the pituitary gland, Deslorelin is primarily used for the initial flare effect upon the pituitary, and its associated surge of LH secretion.