Desoximetasone

Title: Desoximetasone
CAS Registry Number: 382-67-2
CAS Name: (11b,16a)-9-Fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
Additional Names: 9a-fluoro-16a-methyl-17-desoxyprednisolone; 9a-fluoro-16a-methyl-D1-corticosterone; desoxymethasone
Manufacturers' Codes: A-41-304; R-2113; HOE-304
Trademarks: Esperson (HMR); Stiedex LP (Stiefel); Topicort (HMR); Topisolon (HMR)
Molecular Formula: C22H29FO4
Molecular Weight: 376.46
Percent Composition: C 70.19%, H 7.76%, F 5.05%, O 17.00%
Literature References: Prepn: R. Joly et al., FR 1296544; eidem, US 3099654 (1962, 1963 to Roussel-UCLAF); BE 614196; Kieslich et al., US 3232839 (1962, 1966 to Schering AG); R. Joly et al., Arzneim.-Forsch. 24, 1 (1974). Activity studies: Branceni et al., Steroids 6, 451 (1965); Schröder et al., Arzneim.-Forsch. 24, 3 (1974). NMR data: Lukacs et al., C.R. Seances Acad. Sci. Ser. C 274, 1458 (1972). Review of pharmacology and therapeutic efficacy in dermatoses: R. C. Heel et al., Drugs 16, 302-321 (1978).
Properties: Crystals from ethyl acetate, mp 217°. [a]D +109° (chloroform). uv max: 238 nm (e 15750). Sol in alcohol, acetone, chloroform, hot ethyl acetate; slightly sol in ether, benzene. Insol in water, dil aq acids and alkalies.
Melting point: mp 217°
Optical Rotation: [a]D +109° (chloroform)
Absorption maximum: uv max: 238 nm (e 15750)
Therap-Cat: Anti-inflammatory; glucocorticoid.
Keywords: Glucocorticoid.
Dess-Martin Periodinane Desthiobiotin Destomycin A Detaxtran Detomidine

Desoximetasone
Desoximetasone.png
Systematic (IUPAC) name
(8S,9S,10S,11S,13S,14S,16R,17S)-9-Fluoro-11- hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl- 7,8,11,12,14,15,16,17-octahydro-6H- cyclopenta[a]phenanthren-3-one
Clinical data
Trade names Topicort
AHFS/Drugs.com monograph
MedlinePlus a605026
Legal status Prescription only
Routes Topical
Identifiers
CAS number 382-67-2 YesY
ATC code D07AC03
D07XC02 (combinations)
PubChem CID 5311067
DrugBank DB00547
ChemSpider 21117768 YesY
UNII 4E07GXB7AU YesY
KEGG D03697 YesY
ChEMBL CHEMBL1766 N
Chemical data
Formula C22H29FO4 
Mol. mass 376.462 g/mol
 N (what is this?)  (verify)

Desoximetasone is a medication belonging to the family of medications known as topical corticosteroids. It is used for the relief of various skin conditions, including rashes. It helps to reduce redness, itching, and irritation.[1] Desoximetasone is a synthetic corticosteroid, a class of primarily synthetic steroids used as anti-inflammatory and anti-pruritic agents.

There are two brand name products:

  • Topicort Emollient Cream (0.25% desoximetasone)
  • Topicort LP Emollient Cream (0.05% desoximetasone)