Detomidine

Title: Detomidine
CAS Registry Number: 76631-46-4
CAS Name: 4-[(2,3-Dimethylphenyl)methyl]-1H-imidazole
Additional Names: 4-(2¢,3¢-dimethylbenzyl)imidazole
Molecular Formula: C12H14N2
Molecular Weight: 186.25
Percent Composition: C 77.38%, H 7.58%, N 15.04%
Literature References: a2-Adrenoceptor agonist with sedative and analgesic activity. Prepn: A. J. Karjalayne, K. O. A. Kurkela, EP 24829; eidem, US 4443466 (1981, 1984 both to Farmos). Physical studies: E. Laine et al., Acta Pharm. Suec. 20, 451 (1983). Crystal structure: L. H. J. Lajunen et al., ibid. 21, 163 (1984). Pharmacology: R. Virtanen, L. Nyman, Eur. J. Pharmacol. 108, 163 (1985); R. Virtanen, E. MacDonald, ibid. 115, 277 (1985). Mechanism of action: eidem, J. Vet. Pharmacol. Ther. 8, 30 (1985).
Properties: Crystals from acetone, mp 114-116°. LD50 i.v. in mice: 35 mg/kg (Karjalayne, Kurkela).
Melting point: mp 114-116°
Toxicity data: LD50 i.v. in mice: 35 mg/kg (Karjalayne, Kurkela)
Derivative Type: Hydrochloride
Trademarks: Domosedan (Farmos)
Molecular Formula: C12H14N2.HCl
Molecular Weight: 222.71
Percent Composition: C 64.72%, H 6.79%, N 12.58%, Cl 15.92%
Properties: Crystals, mp 160°. Converts reversibly to monohydrate at room temp, 80% humidity.
Melting point: mp 160°
Therap-Cat-Vet: Sedative.
Detoxin Complex Deuterium Oxide Dexamethasone Dexanabinol Dexetimide

Detomidine
Detomidine.png
Systematic (IUPAC) name
4-[(2,3-dimethylphenyl)methyl]-3H-imidazole
Clinical data
AHFS/Drugs.com International Drug Names
Legal status Veterinary use only
Pharmacokinetic data
Half-life 30 min
Identifiers
CAS number 86347-15-1 N
ATCvet code QN05CM90
PubChem CID 56032
ChemSpider 50586 YesY
UNII 7N8K34P2XH YesY
KEGG D07795 N
ChEMBL CHEMBL2110829 N
Chemical data
Formula C12H14N2 
Mol. mass 186.253 g/mol
 N (what is this?)  (verify)

Detomidine is an imidazole derivative and α2-adrenergic agonist, used as a large animal sedative, primarily used in horses. It is usually available as the salt detomidine hydrochloride. It is a prescription medication available to veterinarians sold under the trade name Dormosedan.

Currently, detomidine is only licenced for use in horses.