Dexmedetomidine

Title: Dexmedetomidine
CAS Registry Number: 113775-47-6
CAS Name: 4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
Additional Names: d-medetomidine
Manufacturers' Codes: MPV-1440
Molecular Formula: C13H16N2
Molecular Weight: 200.28
Percent Composition: C 77.96%, H 8.05%, N 13.99%
Literature References: a2-Adrenergic agonist; (+)-isomer of medetomidine, q.v. Prepn: A. J. Karjalainen et al., GB 2206880; eidem, US 4910214 (1989, 1990 both to Farmos). Physical properties: R. Rajala et al., Eur. J. Pharm. Sci. 1, 219 (1994). Clinical pharmacokinetics: P. Talke et al, Anesth. Analg. 85, 1136 (1997). Clinical evaluation as anesthetic adjunct: J. Jalonen et al., Anesthesiology 86, 331 (1997). Review of pharmacology and clinical experience for sedation of patients in intensive care: N. Bhana et al., Drugs 59, 263-270 (2000).
Derivative Type: Hydrochloride
CAS Registry Number: 145108-58-3
Trademarks: Precedex (Abbott)
Molecular Formula: C13H16CN2.HCl
Molecular Weight: 248.75
Percent Composition: C 67.60%, H 6.89%, N 11.26%, Cl 14.25%
Properties: White or almost white crystalline powder, mp 156.5-157.5°. d 1.17 g/cm3. [a] +52.4° (c = 1 in water). pH of 1% soln in water: 4.3.
Melting point: mp 156.5-157.5°
Optical Rotation: [a] +52.4° (c = 1 in water)
Density: d 1.17 g/cm3
Therap-Cat: Sedative; analgesic.
Keywords: a-Adrenergic Agonist; Sedative/Hypnotic.
Dextran Dextran Sulfate Sodium Dextranase Dextranomer Dextri-Maltose?

Dexmedetomidine
Dexmedetomidine skeletal.svg
Systematic (IUPAC) name
(S)-4-[1-(2,3-Dimethylphenyl)ethyl]-3H-imidazole
Clinical data
Trade names Precedex, Dexdor, Dexdomitor
AHFS/Drugs.com monograph
Pregnancy cat. C (US)
Legal status -only (US)
Routes Intravenous infusion only
Pharmacokinetic data
Protein binding 94%
Metabolism Near complete hepatic metabolism to inactive metabolites
Half-life 2 hours
Excretion Urinary
Identifiers
CAS number 113775-47-6 YesY
ATC code N05CM18
PubChem CID 68602
DrugBank DB00633
ChemSpider 4470605 YesY
UNII 67VB76HONO YesY
KEGG D00514 YesY
ChEBI CHEBI:4466 YesY
ChEMBL CHEMBL778 YesY
Chemical data
Formula C13H16N2 
Mol. mass 200.28 g/mol
 YesY (what is this?)  (verify)

Dexmedetomidine (trade names Precedex, Dexdor, Dexdomitor) is a sedative medication used by intensive care units and anesthesiologists. It is relatively unusual in its ability to provide sedation without causing respiratory depression. Like clonidine, it is an agonist of α2-adrenergic receptors in certain parts of the brain.[1] It is the S-enantiomer of medetomidine,[2] used in veterinary medicine. Dexmedetomidine hydrochloride is also used in veterinary medicine for use in dogs and cats.[3] The drug was developed by Orion Pharma.[4]