Dibromochloropropane

Title: Dibromochloropropane
CAS Registry Number: 96-12-8
CAS Name: 1,2-Dibromo-3-chloropropane
Additional Names: 3-chloro-1,2-dibromopropane; DBCP
Manufacturers' Codes: OS-1897
Trademarks: Fumazone; Nemafume; Nemagon
Molecular Formula: C3H5Br2Cl
Molecular Weight: 236.33
Percent Composition: C 15.25%, H 2.13%, Br 67.62%, Cl 15.00%
Line Formula: ClCH2CHBrCH2Br
Literature References: Prepn: Darmstädter, Ann. 152, 320 (1869). Activity: C. W. McBeth, G. B. Bergeson, Plant Dis. Rep. 39, 223 (1955). Toxicity study: T. R. Torkelson et al., Toxicol. Appl. Pharmacol. 3, 545 (1961). Carcinogenicity studies: W. A. Olsen et al., J. Natl. Cancer Inst. 51, 1993 (1973); E. K. Weisburger, Environ. Health Perspect. 21, 7 (1977). Mutagenicity study: H. S. Rosenkranz, Bull. Environ. Contam. Toxicol. 14, 8 (1975). Review of toxicology and human exposure: Toxicological Profile for 1,2-Dibromo-3-chloropropane (PB93-110906, 1992) 164 pp.
Properties: Brown liq; pungent odor. bp 196°; bp16 78°; bp0.8 21°. d14 2.093. nD14 1.553. Vapor press at 21°: 0.8 mm Hg. Slightly sol in water; misc with oils, dichloropropane, isopropyl alcohol. LD50 in rats, mice (g/kg): 0.17, 0.26 orally (Torkelson).
Boiling point: bp 196°; bp16 78°; bp0.8 21°
Index of refraction: nD14 1.553
Density: d14 2.093
Toxicity data: LD50 in rats, mice (g/kg): 0.17, 0.26 orally (Torkelson)
CAUTION: Potential symptoms of overexposure are drowsiness; nausea, vomiting; irritation of eyes, nose, throat and skin; pulmonary edema; liver and kidney injury; sterility. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 92. See also Clinical Toxicology of Commercial Products, R. E. Gosselin et al., Eds. (Williams & Wilkins, Baltimore, 5th ed., 1984) Section II, pp 167-168. This substance is reasonably anticipated to be a human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-81.
Use: Soil fumigant; nematocide; intermediate in organic synthesis.
Dibromogallic Acid Dibromopropamidine Dibromsalicil Dibucaine Dibutoline Sulfate

1,2-Dibromo-3-chloropropane
1,2-Dibromo-3-chloropropane.svg
1,2-Dibromo-3-chloropropane3d.png
Identifiers
Abbreviations DBCP
CAS number 96-12-8 YesY
ChemSpider 7008 YesY
UNII 96K0FD4803 YesY
KEGG C14336 YesY
Jmol-3D images Image 1
Properties
Molecular formula C3H5Br2Cl
Molar mass 236.33 g mol−1
Appearance Dense yellow or amber liquid with a pungent odor at high concentrations
Density 2.05 g/mL
Melting point 6.1 °C; 43.0 °F; 279.2 K
Boiling point 195.5 °C; 383.9 °F; 468.6 K
Hazards
GHS pictograms GHS-pictogram-skull.svgGHS-pictogram-silhouete.svg[1]
GHS hazard statements H301 - H340 - H350 - H360 - H373 - H412[1]
GHS precautionary statements P201 - P273 - P301+P310 - P308+P313[1]
Flash point 76.7 °C; 170.1 °F; 349.8 K
U.S. Permissible
exposure limit (PEL)
TWA 0.001 ppm
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

1,2-Dibromo-3-chloropropane, (dibromochloropropane) better known as DBCP, is the active ingredient in the nematicide Nemagon, also known as Fumazone.

It is a soil fumigant formerly used in American agriculture. In mammals it causes male sterility at high levels of exposure. After discovery of its deleterious health effects on humans, the compound was banned from use in 1979 by the United States Environmental Protection Agency (EPA).[2] The continuing presence of the chemical as a contaminant in ground water remains a problem for many communities for years after end of use.